Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Development and Characterization of Liquisolid Tablets Based on Mesoporous Clays or Silicas for…
The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing…
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Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of…
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under investigation for their aptitude to enhance the oral bioavailability of poorly water-soluble drugs. The cholesterol-lowering agent, simvastatin (SIM), is poorly water-soluble and undergoes extensive…
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Convert oily actives (CBD oil) into flowable and compressible powder
FujiSil™ is a highly porous silica material. It allows you to convert oily actives into flowable and compressible powder. It is ideal for formulations with CBD oil.
Very high adsorption capability
Turn your oily active into a free-flowing powder
Multi-functional spherical highly porous…
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Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica…
Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack…
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Solidification of SMEDDS by fluid bed granulation and manufacturing of fast drug release tablets
Solidification of self-microemulsifying drug delivery systems (SMEDDS) is a rising experimental field with important potential for pharmaceutical industry, however fluid-bed granulation with SMEDDS is yet an unexplored solidification technique. The aim of the study was to solidify carvedilol-loaded…
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Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals— The…
In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid® XDP 3050 and Syloid® 244 FP) were employed. The crystallization tendency of SVT…
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Solubility Improvement of Progesterone from Solid Dispersions Prepared by Solvent Evaporation and…
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate…
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Surface engineered excipients: Improved functional properties of fine grade microcrystalline…
03. December 2017
Abstract
Excipients with good flowability, bulk density as well as compaction properties are desired for use in tableting since they play important roles in formulation development and processing, including, handling, mixing, feeding and compaction.…
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improvement of fine powders through nano-coating
25. October 2017
Majority of the pharmaceutical dosage forms are manufactured from powders as a starting material. The handling and processing problems in pharmaceutical manufacturing still revolves around unpredictable bulk behavior of powders in different manufacturing conditions.…
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Silica Pharmaceutical Excipient: Protect From Moisture, Enhance Shelf Life, Improve Flow
21. July 2016
Applications of SYLOID® FP silica in Oral Dry Suspension of Antibiotics
Unique silica helps to protect antibiotic formulations from moisture
Helps enhances the storage stability and shelf life of finished dosage forms
Helps improves the flow and liquid…
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