Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Digital Compounding in Pharmacies: A Pilot Stability Study †
The manufacture of medicines on demand for a particular patient, at the point of care, may be achieved via 3D printing, improving therapeutic outcomes, medication adherence and patient safety. Tablets are often printed using a combination of hot-melt extrusion and fused deposition modelling. In this…
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Selection of Silica Type and Amount for Flowability Enhancements via Dry Coating: Contact Mechanics…
Abstract
Purpose
To investigate the effect of dry coating the amount and type of silica on powder flowability enhancement using a comprehensive set of 19 pharmaceutical powders having different sizes, surface roughness, morphology, and aspect ratios, as well as assess flow predictability via…
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Effect of process parameters in high shear granulation on characteristics of a novel co-processed…
In this study, insights into the development and optimization of a co-processed excipient based on mesoporous silica are presented. The main advantage of such a material is that it is appropriate for direct tablet compression and has a sufficiently large specific surface area to be suitable for…
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Effects of Phospholipid Structure on the Acoustic Cavitation of Functionalized Mesoporous Silica…
This study investigates the acoustic response of phospholipid-coated, hydrophobically modifed mesoporous silica nanoparticles (PL-HMSNs) for image-guided drug delivery. PL-HMSNs were first stabilized with a PEGylated lipid, DSPE-PEG2k-methoxy, and the efect of particle concentration on the…
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AEROSIL® 200 Pharma – well established and ready for tomorrow’s drug production
Continuous manufacturing is one of the greatest trends in the pharmaceutical industry, bringing advantages compared to the traditional batch production:
Quality and cost position of the final medicine is improved
Batch-to-batch variations are eliminated
Intermediate storage becomes…
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Evaluation the Injectability of Injectable Microparticle Delivery Systems on the Basis of Injection…
Background
Subcutaneous injection of biopharmaceutical agents or microparticles is challenging due to issues with low injection efficiency and high residual amounts.
Objective
This study aimed to determine the important factors affecting the injectability of microparticle delivery…
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The processes behind drug loading and release in porous drug delivery systems
Porous materials are ubiquitous and exhibit properties suitable for depositing therapeutic compounds. Drug loading in porous materials can protect the drug, control its release rate, and improve its solubility. However, to achieve such outcomes from porous delivery systems, effective incorporation…
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Deep Learning-Based Machine Vision System for In-Line Monitoring of High-Shear Wet Granulation…
Aim
Develop a machine vision system for in-line monitoring of high-shear granulation processes to provide a more reliable and continuous solution for assessing the state of granulation.
Introduction
Granulation is critical for pharmaceutical production, but inherently complex and poorly…
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Comprehensive powder flow characterization with reduced testing
Powder flow is a critical attribute of pharmaceutical blends to ensure tablet weight uniformity and production of tablets with consistent and reproducible properties. This study aims at characterizing different powder blends with a number of different rheologic techniques, in order to understand how…
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Influence of Pore Size and Surface Functionalization of Mesoporous Silica Nanoparticles on the…
Coenzyme Q10 is a potent antioxidant that plays an important role in the maintenance of various biochemical pathways of the body and has a wide range of therapeutic applications. However, it has low aqueous solubility and oral bioavailability. Mesoporous silica nanoparticles (MCM-41 and SBA-15…
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