Mesoporous Silica: for solubility enhancement of challenging compounds
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Silica
Milling-Assisted Loading of Drugs into Mesoporous Silica Carriers: A Green and Simple Method for…
Mesoporous silica (MPS) carriers are considered as a promising strategy to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. The development by the authors of a solvent-free method (milling-assisted loading, MAL) made it possible to manipulate the…
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SIPERNAT®, ZEOFREE® and AEROSIL® for Spray Drying Operations – Technical information by Evonik
Introduction
Spray drying is a common process to isolate solid products from emulsions, dispersions or solutions.
A wide range of products are produced by spray drying:
Food products
(e.g., tomato powder, soup mixes, flavors,
non-dairy creamer, egg powder)
Milk and Dairy products…
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Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application
Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell…
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Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The…
Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadings (DL) was used in multi-component blends to…
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Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New…
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Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and Neusilin® US2) through a screening plan. The enhancement of…
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Cationic Solid SMEDDS of Efavirenz for Improved Oral Delivery: Development by Central Composite…
Efavirenz (EFV) is an anti-HIV drug with high dose and 40% oral bioavailability (BA). The aim was to improve the bioavailability by designing cationic solid SMEDDS. Solubility data, ternary phase diagrams, and central composite design were employed in design. Globule size, TEM, DSC, and SEM studies…
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Drugs for neglected tropical diseases: availability of age-appropriate oral formulations for young…
It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (labelling) is a well-recognised problem for all diseases…
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Microcrystalline cellulose promotes superior direct compressed Boesenbergia rotunda (L.) Mansf.…
This work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf. extract tablet. Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried rice starch, and spray-dried lactose were used. MCC exhibited superior performance to the other diluents by providing the…
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The Preparation of Vitamin E Tablets with Fujicalin
See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin® and a comparison with the other commercially available DCPAs.
Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and…
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