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Silicon Dioxide
Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development,…
Drop-on-powder 3D printing is able to produce highly drug loaded solid oral dosage forms. However, this technique is mainly limited to well soluble drugs. The majority of pipeline compounds is poorly soluble, though, and requires solubility enhancement, e.g., via formation of amorphous solid…
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Exposing Profound Screening Potential of Ethanol-Based Dissolution Media in the Development of…
Characterization of drug release from modified-release products in the presence of alcohol is required to evaluate the possibility of dose dumping due to safety assurance reasons. A generic product containing BCS IV drug and HPMCAS polymer was formulated as amorphous solid dispersion with hot-melt…
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Overview on Functionality Added Co-processed Excipients for Orodispersible Tablets
Orally disintegrating tablets are an emerging trend in novel drug delivery system and have received ever increasing demand during the last few decades. Orally disintegrating tablets ODTs are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property…
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Drug delivery to the targeted site of action in the human body is always affected by the excipients used and almost in the same manner by some processing variables like changes in the compression force. The aim of this study was to investigate the impact of the changes in compression forces during…
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Development of Liquisolid Compacts: An Approach for Dissolution Enhancement of Poorly Aqueous…
Solubility plays a key role to achieve desired concentration of drug in systemic circulation and show its pharmacological action. An approach of liquisolid technique, developed by Spireas, was employed for the dissolution enhancement of poorly aqueous soluble drugs. Initially, liquid medication…
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AEROSIL® Pharma colloidal silicon dioxide – technical information
Evonik is one of the world’s leading CDMOs for advanced drug delivery. Our integrated portfolio of functional excipients, technologies and services for the formulation development, process scale-up and cGMP manufacturing of complex oral and parenteral drug products can reduce your project risk,…
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Comparison of Various Fillers on the Physical Properties of Compounded Tablets
Abstract
Compounded tablets are solid dosage forms that contain active pharmaceutical ingredients that are usually formulated with suitable pharmaceutical excipients. Fillers are inert ingredients used as bulking agents that can affect the physical properties of the final compounded tablet. The…
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The Stability of Probiotics in Pharmaceutical Products
Abstract
Due to their large potential applications in human diseases such as gastrointestinal disorders, immunomodulation or cholesterol reduction, probiotic products are of great interest to the pharmaceutical industry. The formulation of the pharmaceutical forms containing probiotics aims the…
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DiCom SANAQ® SP205 / SP206 – Co-processed excipient for direct compression of hygroscopie and…
PHARMATRANS SANAQ offers excipients and active ingredients of outstanding quality and performance. With our research & development skill and tradition, we commit to study innovative technological solutions providing excipients contributing successfully to smart and efficient pharmaceutical…
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In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule
Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place and the potential degradation of fragile APIs…
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