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Silicon Dioxide
Influence of commonly used excipients on the chemical degradation of enalapril maleate in its solid…
The physicochemical stability of enalapril maleate was investigated in the presence of fourteen different excipients divided into four different classes. The extent of a drug-excipient interaction was investigated by following the chemical stability using HPLC. It was found that there is a certain…
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Advances in the Treatment of Inflammatory Bowel Disease: Focus on Polysaccharide Nanoparticulate…
The complex pathogenesis of inflammatory bowel disease (IBD) explains the many hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to reduce inflammation during the hot phase or maintain remission during the cold phase. Nonetheless, these drugs suffer from…
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Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of…
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in various pharmaceutical fields of interest. We…
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Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to…
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through the design of experiments and identified the…
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Enhanced Supersaturation via Fusion-Assisted Amorphization during FDM 3D Printing of Crystalline…
Filaments loaded with griseofulvin (GF), a model poorly water-soluble drug, were prepared and used for 3D printing via fused deposition modeling (FDM). GF was selected due to its high melting temperature, enabling lower temperature hot-melt extrusion (HME) keeping GF largely crystalline in the…
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Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum…
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance).…
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Formulation and In Vivo Evaluation of a Solid Self-Emulsifying Drug Delivery System Using Oily…
Self-emulsifying drug delivery systems (SEDDS) can improve the oral bioavailability of poorly water-soluble drugs. Solid self-emulsifying drug delivery systems (s-SEDDS) offer several advantages including improved drug stability, ease of administration, and production. Most compounds employed in…
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Opposing Effects of Additives in Dry Milling and Tableting of Organic Particles
Applying additives and excipients during the dry processing of fine particles is a common measure to control the particle–particle interactions, to specifically influence the powder properties and to enhance the process efficiency or product quality. In this study, the impacts of a particulate…
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Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential…
At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets. These interactions were observed during an…
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Oil adsorption with Fuji excipients
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. We spray-dry our excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. Our products are ideal when it…
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