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Skin delivery
Design Development and Evaluation of Nanostructured Lipid Carrier Loaded Emulgel of Voriconazole
Voriconazole is a second generation triazole derived from fluconazole. Voriconazole is used for the treatment of various fungal infections. Though it has excellent antifungal activity, there are several side effects associated with it. In order to overcome these limitations, nanostructures may be an…
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Encapsulation of cannabidiol in oil-in-water nanoemulsions and nanoemulsion-filled hydrogels: a…
Abstract
Hypothesis
Lipophilic cannabidiol can be solubilized in oil-in water nanoemulsions, which can then be impregnated into chitosan hydrogels forming another colloidal system that will facilitate cannabidioil's release. The delivery from both systems was compared, alongside structural and…
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Nanochannel delivery system for CBD: Sustained low level plasma levels without liver toxicity
Cannabidiol (CBD) is a plant-derived cannabinoid found in marijuana and hemp that has been intensely investigated for its putative anti-inflammatory, anxiolytic and/or analgesic effects. Since all these conditions require long-term treatment, sustained release formulations are being investigated.…
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Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized…
Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from…
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Development and optimization of ganciclovir-loaded carbopol topical gel by response surface…
Low permeability is one of the barriers to the bioavailability of drugs through the oral route. The purpose of the present study was to design and optimize a sustained release and highly permeable hydrogel formulation of ganciclovir (GCV) by using response surface methodology (RSM). Carbopol 934P…
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Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and…
The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to…
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Phospholipids in Pharmaceutical Form Line Extensions
The pharmaceutical industry has two main ways to generate new products. The first option is to look for new drug substances. A second option is to employ better formulations of an existing drug product. Such reformulated products are called Pharmaceutical Form Line Extensions. As part of such a…
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Development and Characterisation of a Topical Methyl Salicylate Patch: Effect of Solvents on…
The advent of skin patch formulation design and technology has enabled the commercialisation of methyl salicylate (MS) as a topical patch. However, the most fundamental aspect of skin permeation is unknown at present. The study aims to investigate the effect of solvent choice on the skin permeation…
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Solid microneedle assisted transepidermal delivery of iloperidone loaded film: Characterization and…
Transepidermal microneedle-assisted drug delivery is an alternative approach that can improve the therapeutic permeability of the drug in the deeper layers of the skin. The project aims to check the effect of a microneedle roller on transepidermal delivery of Iloperiodone across the neonatal porcine…
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Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous…
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards poorly soluble drugs and promote/sustain drug…
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