Browsing Category
Skin delivery
Formulation and Evaluation of the In Vitro Performance of Topical Dermatological Products Containing…
The selection of an appropriate vehicle in a semi-solid topical product is of utmost importance since the vehicle composition and microstructure can potentially cause changes in drug–vehicle or vehicle–skin interactions and affect drug release and subsequent permeation into and across skin. Hence,…
Read More...
Read More...
The use of natural gums to produce nano-based hydrogels and films for topical application
Natural gums are a source of biopolymeric materials with a wide range of applications for multiple purposes. These polysaccharides are extensively explored due to their low toxicity, gelling and thickening properties, and bioadhesive potential, which have sparked interest in researchers given their…
Read More...
Read More...
Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems
Arthritis is a general term for various types of inflammatory joint diseases. The most common clinical conditions are mainly represented by rheumatoid arthritis and osteoarthritis, which affect more than 4% of people worldwide and seriously limit their mobility. Arthritis medication generally…
Read More...
Read More...
Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis…
Osteoarthritis (OA) is a prevalent degenerative disease that has a significant impact on patients' lives. Celecoxib (CXB) is now primarily used to treat OA with oral dosing. CXB's limited water solubility, on the other hand, restricts its therapeutic application. We developed a delivery system of…
Read More...
Read More...
Microneedles assisted controlled and improved transdermal delivery of high molecular drugs via in…
Skin is considered as an attractive route for variety of drug molecule administration. However, it is proved to be the main physical barrier for drug flux owing to their poor permeability and low bioavailability across stratum corneum layer. In the current study, novel approach has been used to…
Read More...
Read More...
Ionic liquids in transdermal drug delivery system: Current applications and future perspectives
The transdermal drug delivery (TDD) shows considerable advantages over other administration pathways. However, conventional enhancing permeation methods face a series of challenges owing to barrier function provided by the skin, of which enhancing abilities either are so strong that it results in…
Read More...
Read More...
Polymer Coated Polymeric (PCP) Microneedles for Controlled Delivery of Drugs (Dermal and…
Microneedles are used to deliver drugs topically across the skin and mucous membranes. Dissolvable microneedles are made using soluble polymers, which disintegrates in the tissue and release the entire payload instantaneously including the polymer construct. Often, a slow release of drug into the…
Read More...
Read More...
Pain management with transdermal drug administration: A review
Pain management is an urgent issue to solve with complex mechanisms. Localized acute pain requires rapid and accurate delivery of drugs with less distribution in the blood circulation while chronic pain requires controlled release of drugs with long drug retention time.
The transdermal route, a…
Read More...
Read More...
Nanocarriers for promoting skin delivery of therapeutic agents
Compared to oral and injectable administration, a dermal and transdermal drug delivery system that can deliver therapeutic molecules to desired target sites with noninvasive, low toxicity, and convenient self-application is a unique method with high potential and excellent prospects. However, the…
Read More...
Read More...
Investigation of the effect of polymers on dermal foam properties using the QbD approach
Dermal foams are promising drug delivery systems due to their many advantages and ease of application. Foams are also considered a novelty in the field of dermatology. In particular, they are beneficial for the treatment of skin conditions where patients have highly inflamed, swollen, infected and…
Read More...
Read More...