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Skin delivery
Combination of lipid nanoparticles and iontophoresis for enhanced lopinavir skin permeation: Impact…
Nanostructured lipid carriers (NLC)-loaded with lopinavir (LPV) were developed for its iontophoretic transdermal delivery. Electronic paramagnetic resonance (EPR) spectroscopy of fatty acid spin labels and differential scanning calorimetry (DSC) were applied to investigate the lipid dynamic behavior…
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Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification…
Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H1-antihistaminic activity…
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Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration
Alkanediols are widely used as multifunctional ingredients in dermal formulations. In addition to their preservative effect, considering their possible impact on drug penetration is also essential for their use. In the present study, the influence of 2-methyl-2,4-pentanediol, 1,2-pentanediol,…
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Tacrolimus Encapsulated Mesoporous Silica Nanoparticles Embedded Hydrogel for the Treatment of…
Atopic dermatitis (AD) is a repetitive inflammatory skin disorder with limited treatment options. Innovative targeted therapies are gaining significant interest and momentum towards disease control including better ways to deliver drugs topically. Tacrolimus is one such compound which is used to…
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Bioadhesive liquid crystal systems for octyl methoxycinnamate skin delivery
Excessive exposure to ultraviolet radiation stemmed from sunlight can cause harm to human skin. An alternative to avoid and reduce the effects of ultraviolet radiation is the use of sunscreens. The sunscreen octyl methoxycinnamate (OMC) is one of the most used filters globally. Still, studies have…
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Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer
Highlights
• Microneedles are promising devices used for painless transdermal drug delivery.
• Biological effects of therapeutic agents can be improved by tuning their release behavior.
• Microneedles can be employed for immunotherapy.
• Combinatory approaches with…
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Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair
The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually…
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Exploring the affluent potential of glyceryl mono oleate – myristol liquid crystal nanoparticles…
This study aimed to design and characterize Tofacitinib (TF)-loaded lyotropic liquid crystalline nanoparticles (TF-LCNP) gel using quality by design-driven approach to enhance the skin delivery of TF. The present work investigated the impact of two different liquid lipids on different critical…
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Development of a thermostable oxytocin microneedle patch
Oxytocin is a nonapeptide hormone used in labor to initiate uterine contractions and to prevent and treat postpartum hemorrhage. Oxytocin is currently administered by injection and requires refrigerated transport and storage, which limits access, especially during home birth in developing countries.…
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Film-Forming Systems for Dermal Drug Delivery
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation. By evaporation of the volatile solvent on the skin, the polymer contained in the formulation forms a solid film. Various film-forming…
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