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Skin delivery
Diving into 3D (bio)printing: A revolutionary tool to customize the production of drug and…
The incorporation of 3D printing technologies in the pharmaceutical industry can revolutionize its R&D, by providing a simple and rapid method to produce tailored one-off batches, each with customized dosages, different compounds, shapes, sizes, and adjusted release rates. Particularly, this…
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Formulation development and evaluation of nimesulide transdermal gel patch system
The objective was to develop a reservoir-type nimesulide gel patch for controlled drug delivery and avoid the gastrointestinal adverse effects associated with the oral delivery of nimesulide. Six patch formulations of nimesulide gel comprising of 20–40% for ethanol and 20–40% for propylene glycol as…
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Efficacy of topical risedronate and risedronate – Eudragit E complex in a model of cutaneous…
An efficacious topical treatment for cutaneous leishmaniasis (CL) is highly desirable but still an ongoing challenge. Systemic risedronate (Ris) has been reported to have anti-leishmanial properties and Eudragit EPO (EuE) has shown in vitro activity against L. (L.) amazonensis. The aim of this work…
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Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization
This research aimed to develop a novel drug delivery system to improve treatment of skin disorders. The system is comprised of a Carbopol 980-based nanoemulgel (NE-gel) containing a desonide (DES; 0.05%, w/w) nanoemulsion (NE), which has a small particle size, high encapsulation efficiency,…
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Brucine-loaded transliposomes nanogel for topical delivery in skin cancer: statistical optimization,…
The aim of the present study was to develop, optimize brucine-loaded transliposomes (BRC-TL) formulation for dermal delivery of brucine for skin cancer. The BRC-TL formulations were evaluated for vesicle size, entrapment efficiency, and in vitro drug release. The optimized formulation was further…
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Delivering therapeutic cannabinoids via skin: Current state and future perspectives
Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over…
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Potential and Applications of Nanocarriers for Efficient Delivery of Biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly increased because of their obvious advantages over conventional small-molecule drug products. These advantages include better specificity, potency, targeting abilities, and reduced side effects. Despite the…
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Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin…
In the present study, combinatorial nanostructured lipid carrier gel of 5-fluorouracil and resveratrol was formulated, optimized and characterized to enhance permeation in between epidermis and dermis layers of the skin to obtain a synergistic effect against skin cancer. After extensive trials, a…
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Importance of Nanoparticles for the Delivery of Antiparkinsonian Drugs
Parkinson’s disease (PD) affects around ten million people worldwide and is considered the second most prevalent neurodegenerative disease after Alzheimer’s disease. In addition, there is a higher risk incidence in the elderly population. The main PD hallmarks include the loss of dopaminergic…
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Skin penetration/permeation success determinants of nanocarriers: Pursuit of a perfect formulation
The advent of nanocarriers in the field of pharmaceutical drug delivery, while exhibiting considerable advantages, has created challenges for researchers. Among the applications of nanocarriers, drug delivery to the skin has attracted increasing attention in recent decades due to its advantages over…
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