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Skin delivery
Programmable immune activating electrospun fibers for skin regeneration
Immune cells play a crucial regulatory role in inflammatory phase and proliferative phase during skin healing. How to programmatically activate sequential immune responses is the key for scarless skin regeneration. In this study, an “Inner-Outer” IL-10-loaded electrospun fiber with cascade release…
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Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro
Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could…
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Rheological and Drug Delivery Characteristics of Poloxamer-Based Diclofenac Sodium Formulations for…
Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low temperatures but gels at higher temperatures, is well suited…
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The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles
Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin.
The role of EVs and their contents, including RNA,…
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Polymers Used in Peyer’s Patch Targeting
Peyer’s Patches (PPs) consist of transmucosal clusters of lymphoid follicles overlaid with a specialized lymphoepithelium and play an essential role in the initiation of mucosal immune responses in the gut. Regardless of extensive achievements in the last few decades, for our understanding we will…
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Polymers in Transdermal Drug Delivery
Current researches in the branch of polymer-mediated transdermal drug delivery systems (DDSs) are one of the most promising approaches as it bypasses the hepatic first-pass metabolism and improves patient compliance. The main barrier to drug permeation is stratum corneum, and the cutaneous…
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Pharmacokinetics and Biodistribution of Tacrolimus after Topical Administration: Implications for…
Aim
The high doses of oral tacrolimus (TAC) (1,2) necessary to prevent acute rejection (AR) after vascularized composite allotransplantation (VCA) are associated with systemic adverse effects. The skin is the most antigenic tissue in VCA and the primary target of AR. However, the short-term use of…
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Transcutol® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery
Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation. The employment of classical 8-MOP vehicles in topical PUVA therapy is associated with poor skin deposition and…
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Film forming systems for topical and transdermal drug delivery
Methyl ester derivatives of alginic acid have been evaluated as potential multifunctional excipients for pharmaceutical direct compression. The use of alginic acid as an excipient in tablet formulation is limited because of certain drawbacks such as low tablet hardness and poor compressibility. The…
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A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for…
Although dissolving microneedles have garnered considerable attention as transdermal delivery tools, insufficient drug loading remains a challenge owing to their small dimension. Herein, we report a one-step process of synthesizing semi-dissolving microneedle (SDMN) patches that enable effective…
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