Skin delivery

Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effects. Dissolving microneedle has sharp tips and short length, which overcome patients’ pain and improve transdermal efficiency but has low mechanical strength and drug loading…
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Abstract Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues.…
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Skin cancer chemotherapeutics often lead to the development of severe cytotoxicity, compelling the development of novel delivery systems to not only enhance therapeutic efficacy but also minimize side effects and improve patient compliance. In recent years, topical nanoemulsions have emerged as…
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Abstract Imiquimod (IMQ) is an immunostimulating agent used in the treatment of basal cell carcinoma and actinic keratosis. Due to its low solubility and poor skin bioavailability, the dermal formulation of IMQ remains challenging. In analogy to tyre compounds used in Formula 1 racing, we compare…
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Abstract Purpose The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems (THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac diethylamine (DDEA), a non-steroidal anti-inflammatory drug. The research question focuses on whether THEDES…
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Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours) pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran) and amino acids, and doped with antibacterial nanoparticles (CuO or ZnO…
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ABSTRACT The study was to develop an antiviral gel for topical application. The topical application of drug has many advantages over the intravenous and oral administration. It prevents metabolism of drug from liver and avoid the risk of gastrointestinal disorder and inconvenience of intravenous…
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Introduction: This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. Methods: A systematic and comprehensive literature search across academic databases, search…
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Most antibiotics used in topical formulations are not absorbed by deeper skin layers and subdermal tissues. Hence the skin infections are treated with large doses of oral or parenteral antibiotics which lead to unpleasant side effects with drug resistance. This could be the necessity for the…
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Microneedles (MNs) are microscopic needles that are applied to the skin in a minimally invasive way to facilitate transdermal drug delivery and/or uptake of interstitial fluid from the skin, which contains a variety of metabolites that can serve as biomarkers. The collection of interstitial fluid…
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