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Skin delivery
Tioconazole-Loaded Transethosomal Gel Using Box–Behnken Design for Topical Applications: In Vitro,…
Tioconazole (TCZ) is a broad-spectrum fungicidal BCS class II drug with reported activity against Candida albicans, dermatophytes, and certain Staphylococci bacteria. We report the use of TCZ-loaded transethosomes (TEs) to overcome the skin’s barrier function. TCZ-loaded TEs were fabricated by using…
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A quality by design framework for developing nanocrystal bioenabling formulations
The present study aims to outline a rational framework for the design and development of a 1.0% (w/v) hydrocortisone nanocrystal-based formulation, resorting to a simple, efficient, and scalable nanonization methodology, based on the high-pressure homogenization (HPH) technique. Accordingly, the…
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Xanthan and gum acacia modified olive oil based nanoemulsion as a controlled delivery vehicle for…
In this study, olive oil nanoemulsion modified with xanthan gum and gum acacia was explored as a potential controlled topical delivery vehicle. Oil-in-water nanoemulsion formulated with optimized composition of olive oil, tween 80, and water was used as the drug carrier and further modified with…
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Tazarotene-calcipotriol loaded Nanostructured lipid carrier enriched hydrogel: A novel dual drug…
Psoriasis with unclear etiology and pathogenesis is one of the most prevalent chronic skin diseases. It involves excessive keratinocytes cells hyperproliferation, abnormal vascular infiltration, and differentiation as its characteristic features. Patients need therapy on a periodic basis over a long…
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Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate
Sunburn is caused by prolonged exposure to ultraviolet (UV) rays from the sun, resulting in redness of the skin as well as tenderness, swelling, and blistering issues. During the healing process, it can cause peeling, irritation, and some long-term effects, including premature aging, pigmentation,…
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Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances,…
Information on the penetration depth, pathways, metabolization, storage of vehicles, active pharmaceutical ingredients (APIs), and functional cosmetic ingredients (FCIs) of topically applied formulations or contaminants (substances) in skin is of great importance for understanding their interaction…
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Formulation and in vitro skin diffusion of colchicine using different drug delivery vehicles
Introduction
Historically known as “the disease of kings,” gout is one of the oldest known types of arthritis, affecting more than 40 million people worldwide, prevalent in patients between 30 and 50 years of age, and frequently experienced more by males than females , , , ]. It is a result of…
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Topical Drug Delivery – Excipients for creams, gels, and lotions
Stable and efficient semisolid preparations with optimal skin-feel have become the desirable standard in topical and
transdermal drug delivery. Lubrizol Life Science Health (LLS Health) has long-standing experience with semisolids,
offering rheology-modifying, emulsifying and bioadhesive…
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Micro array patch assisted transdermal delivery of high dose, ibuprofen sodium using…
Current study reports the combined technique of microneedle array patches and thermoresponsive gels. Microneedles array patch mediated in situ skin depots were evaluated for sustain drug delivery using sodium alginate/Poly (vinylcaprolactam) thermoresponsive gels. Their phase transition property…
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Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System
Skin diseases are among the most prevalent non-fatal conditions worldwide. The transdermal drug delivery system (TDDS) has emerged as a promising approach for treating skin diseases, owing to its numerous advantages such as high bioavailability, low systemic toxicity, and improved patient…
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