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Skin delivery
Dissolvable microneedles for transdermal drug delivery showing skin penetration and modified drug…
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility to increase the compliance by acting as a depot in the skin and…
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Skin drug delivery using lipid vesicles: A starting guideline for their development
Lipid vesicles can provide a cost-effective enhancement of skin drug absorption when vesicle production process is optimised. It is an important challenge to design the ideal vesicle, since their properties and features are related, as changes in one affect the others. Here, we review the main…
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3D-printed EVA-based patches manufactured by direct powder extrusion for personalized transdermal…
In recent years, 3D printing has attracted great interest in the pharmaceutical field as a promising tool for the on-demand manufacturing of patient-centered pharmaceutical forms. Among the existing 3D printing techniques, direct powder extrusion (DPE) resulted as the most practical approach thanks…
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Engineered Lipid Excellence For Topical Applications – IOI Oleo
Tried & Trusted, Quality & Innovation
With our nature-based excipients you can develop modern pharmaceutical topical formulations that combine functionality, regulatory compliance and a pleasant skin feel. While the advantages of localized drug delivery for acute conditions are clear, the…
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Recent approaches for enhancing the performance of dissolving microneedles in drug delivery…
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical and pharmaceutical applications. Being made of water-soluble polymers, dMNs own several advantages, including fast dissolution…
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Dissolvable microneedles for transdermal drug delivery showing skin pentation and modified drug…
Topical therapies for chronic skin diseases suffer from a low patient compliance due to the inconvenient treatment regimens of available products. Dissolvable microneedles (MN) with modified release offer an interesting possibility to increase the compliance by acting as a depot in the skin and…
Read More...
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Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery
Abstract
Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety of limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, an amalgamated…
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Formulation and Skin Permeation of Active-Loaded Lipid Nanoparticles: Evaluation and Screening by…
Encapsulation into nanoparticles (NPs) is a potential method to deliver pharmaceutical/cosmetic actives deep into the skin. However, understanding the NP formulations and underlying mechanism of active delivery to skin has scarcely been studied. We report a simulation platform that screens,…
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The role of excipients in promoting topical and transdermal delivery: Current limitations and future…
Topical and transdermal delivery has historically offered an attractive and non-invasive route for administration of medicines. However, human skin is known to be a remarkably good barrier to the permeation of substances. The majority of dermatological drug products have been reported to only…
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Comparative study on the topical and transdermal delivery of diclofenac incorporated in…
Transdermal delivery of active pharmaceutical ingredients (APIs) can be challenging, since the skin possesses a rate-limiting barrier, which may be overcome when APIs possess certain ideal physicochemical properties. The lack thereof would require that APIs be included in drug delivery vehicles to…
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