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Solid Dispersion
Solid Dispersion of Artemether in Fast Disintegrating Tablet to Enhance Dissolution Rate and Oral…
Objectives: Artemether (ART), an antimalarial drug, have poor solubility and low bioavailability. Therefore, solid dispersion of the drug was formulated using Soluplus (SOL) and was incorporated in the fast disintegrating tablet.
Materials and Methods: The solid dispersion (SD) was prepared using…
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Solid Dispersion of Lumefantrine Using Soluplus® by Solvent Evaporation Method: Formulation,…
Objectives: Lumefantrine (LUM) is an antimalarial drug having poor aqueous solubility. The objective was to formulate the solid dispersion of LUM and improve the solubility and dissolution rate.
Materials and Methods: Solvent evaporation technique was used to prepare solid dispersions (SDs) with…
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Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions:…
Nucleation inhibition and maintenance of drug supersaturation over a prolonged period are desirable for improving oral absorption of amorphous solid dispersions. The present study investigates the impact of binary and ternary amorphous solid dispersions on the supersaturation kinetics of nifedipine…
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Hot-melt extrudability of amorphous solid dispersions of flubendazole-copovidone: An exploratory…
The FDA-approved anthelmintic flubendazole has shown potential to be repositioned to treat cancer and dry macular degeneration; however, its poor water solubility limits its use. Amorphous solid dispersions may overcome this challenge, but the balance of excipients may impact the preparation method…
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Role of polymers in the physical and chemical stability of amorphous solid dispersion: A case study…
Incorporating the amorphous drug in polymeric components has been demonstrated as a feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective of this study was to investigate the role of polymers in the stability of amorphous solid dispersion (ASD) by evaluating…
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Improved Bioavailability of Poorly Water-Soluble Drug by Targeting Increased Absorption through…
Itraconazole (ITZ) is a class II drug according to the biopharmaceutical classification system. Its solubility is pH 3-dependent, and it is poorly water-soluble. Its pKa is 3.7, which makes it a weak base drug. The aim of this study was to prepare solid dispersion (SD) pellets to enhance the release…
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Application of Insoluble Excipients in Solid Dispersion of Chinese Medicines
In recent years, as the great success of arteannuin in the area of antimalarial treatment and commercial benefit, traditional Chinese medicine (TCM) has received great attention. However, most of the active pharmaceutical ingredients (API) of Chinese medicines are hydrophobic, which causes the low…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to improve…
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Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion
The oral bioavailability and efficacy of baicalein is dramatically limited by its low solubility and effect of efflux. In our study, we chose PVP-VA 64 as a carrier and TPGS as a plasticizer and efflux inhibitor to prepare a solid dispersion of baicalein using hot-melt extrusion technology to…
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Design and Characterization of HY-038 Solid Dispersions via Spray Drying Technology
The aim of this study was to prepare HY-038 solid dispersions (SDs) with single carrier at high drug loading and then forming a tablet to enhance solubility, dissolution, and bioavailability via spray drying technology. At the same time, we hope to develop a more convenient in vitromethod to predict…
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