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Solid Dispersion
Preparation of solid dispersions with respect to the dissolution rate of active substance
Solid dispersions (SDs) are one of the successfully applied methods to improve the solubility and dissolution rates of poorly water-soluble drugs. SDs are commonly API-polymer systems, where API is molecularly dispersed in a polymeric matrix. The objective of this study was to prepare SDs by…
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Impact of Laser Speed and Drug Particle Size on Selective Laser Sintering 3D Printing of Amorphous…
This research demonstrates the influence of laser speed and the drug particle size on the manufacturing of amorphous solid dispersions (ASD) and dosage forms thereof using selective laser sintering 3-dimensional (3D) printing. One-step manufacturing of ASD is possible using selective laser sintering…
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Application of near-infrared spectroscopy in detecting residual crystallinity in carbamazepine –…
Amorphous solid dispersions can improve the solubility and dissolution rate of poorly soluble drugs. However, residual crystallinity can adversely affect the dissolution in formulations design to be in amorphous state. This study aimed to develop near-infrared spectroscopy (NIRS) as a potential…
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Solvent influence on manufacturability, phase behaviour and morphology of amorphous solid…
Bead coating or fluid-bed coating serves as an auspicious solvent-based amorphous solid dispersion (ASD) manufacturing technique in respect of minimization of potential physical stability issues. However, the impact of solvent selection on the bead coating process and its resulting pellet…
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3D Printed Intragastric Floating and Sustained-release Tablets with Air Chambers
This work aimed to use hot-melt extrusion (HME) and dual fused deposition modeling (FDM) 3D printing technology to develop a novel intragastric floating and sustained-release drug delivery system. The intragastric floating and sustained-release tablet was engineered by employing hydroxypropyl…
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Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based…
Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate…
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High-Pressure Dielectric Studies—a Way to Experimentally Determine the Solubility of a Drug in the…
In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility of the drug in the polymer matrix decreases with increasing pressure, and…
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New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug…
The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid SNEDDS was composed of dexibuprofen,…
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Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug…
We seek to further address the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased bioavailability are not compromised. To address…
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Pulmonary Drug Delivery of Antimicrobials and Anticancer Drugs Using Solid Dispersions
It is well established that currently available inhaled drug formulations are associated with extremely low lung deposition. Currently available technologies alleviate this low deposition problem via mixing the drug with inert larger particles, such as lactose monohydrate. Those inert particles are…
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