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Solid Dispersion
Particle Forming Amorphous Solid Dispersions: A Mechanistic Randomized Pharmacokinetic Study in…
Amorphous solid dispersions (ASDs) are a promising drug-delivery strategy to overcome poor solubility through formulation. Currently, the understanding of drug absorption mechanisms from ASDs in humans is incomplete. Aiming to gain insights in this matter, we conducted a randomized cross-over design…
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Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid…
Silymarin is a mixture of flavonolignans obtained from the seeds of milk thistle (Silybum marianum L. Gaertner). Silymarin behaves as a weak acid and is categorised as a class IV drug substance in accordance with biopharmaceutics drug disposition classification system, possessing low solubility, as…
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Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of…
Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process. However, quantitative prediction of oral absorption from…
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A novel combination of Soluplus ®/Poloxamer for Meloxicam solid dispersions via hot melt extrusion…
Objective: Bioavailability of Meloxicam (MLX) from solid dispersions (SDs), against innovator product Mobic® in humans was conducted. Furthermore, to establish a good in vitro-in vivocorrelation (IVIVC); dissolution studies were carried-out in different media.
Methods: MLX/SDs was prepared using…
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A novel combination of Soluplus® and Poloxamer for Meloxicam solid dispersions via hot melt…
The hot melt extrusion (HME) technique was proposed to prepare solid dispersions (SDs) of the high melting point meloxicam (MLX) for the first time. Extruded MLX/SDs (EXT) prepared by HME were compared with fusion (FUS) and physical mixture (PM) using different ratios of Soluplus® (SOL) to Poloxamer…
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Multicomponent solid dispersion: A new generation of solid dispersion produced by spray-drying
The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of…
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Soluplus solutions as thermothickening materials for topical drug delivery.
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have application topical drug delivery to sites including the…
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Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®
05. June 2018
Due to the high number of poorly soluble drugs in the development pipeline, novel processes for delivery of these challenging molecules are increasingly in demand. One such emerging method is KinetiSol, which utilizes high shear to produce amorphous solid dispersions.…
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Stability-Enhanced Ternary Solid Dispersions with HPMC and Soluplus
24. September 2017
Abstract
The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus®polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was…
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Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion…
Abstract
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation. The bioadhesive floating pellets, loaded with an amorphous…
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