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Solid Dispersion
Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs
19. January 2017
Abstract
The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules such as peptides. We hypothesized that this mechanism could have utility for poorly soluble small molecules by utilizing a mucoadhesive polymer as the…
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Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion…
15. December 2016
Abstract
Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility…
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Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation,…
The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as the model drug, by obtaining an amorphous solid dispersion by hot melt extrusion. Therefore, an initial preformulation study was conducted using differential scanning…
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A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against…
08. February 2015
AJS is the code name of an untitled novel medicative compound synthesized by the Tasly Holding Group Company (Tianjin, China) based on the structure of cinnamamide, which is one of the Biopharmaceutics Classification System (BCS) class II drugs. The drug has…
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