Browsing Category
Solid Dispersion
Formulation, Characterization, and Taguchi Design Study of Eplerenone Lipid-Based Solid Dispersions…
Eplerenone is a potassium-sparing diuretic of aldosterone antagonist employed to treat chronic heart failure and high blood pressure. Eplerenone is classified as a BSC class II drug since it has poor oral absorption and is difficult to absorb in the body. The solid dispersions approach is the most…
Read More...
Read More...
Surface Solid Dispersion Review
Oral route is mostly preferred route for administering drugs to patient. But due to the poor solubility many drug has limited used in oral administration. Enhancement of water solubility of poor water soluble drug is a main target in a pharmaceutical field. Surface solid dispersion is aneffective…
Read More...
Read More...
Effect of different seed crystals on the supersaturation state of ritonavir tablets prepared by…
Hot-melt extrusion (HME) is a technology increasingly common for the commercial production of pharmaceutical amorphous solid dispersions (ASDs), especially for poorly water-soluble active pharmaceutical ingredients (APIs). However, recrystallization of the APIs during dissolution must be prevented…
Read More...
Read More...
Dissolution Mechanisms of Amorphous Solid Dispersions: A Close Look at the Dissolution Interface
Despite the recent success of amorphous solid dispersions (ASDs) at enabling the delivery of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug loading. This is partially due to a sharp decline in drug release from the ASD at drug loadings surpassing the ‘limit of…
Read More...
Read More...
Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting…
Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and facilitate the noninvasive transdermal delivery of many hydrophilic substances. However, their use in the delivery of hydrophobic agents is a challenging task. This work demonstrates, for the first time, the…
Read More...
Read More...
Moisture sorption by polymeric excipients commonly used in amorphous solid dispersions and its…
Moisture sorption by polymeric carriers used in amorphous solid dispersion (ASD) plays a critical role in the physical stability of the dispersed drug as it can increase molecular mobility of drug in ASD by decreasing the glass transition temperatures (Tg) of the drug-polymer system, leading to drug…
Read More...
Read More...
An investigation into solubility and dissolution improvement of alectinib hydrochloride as a…
Poorly water-soluble drugs belonging to BCS Class II and IV present a big challenge to formulators owing to their limited solubility and bioavailability. Alectinib hydrochloride (ALB), a BCS IV molecule, shows very low solubility resulting in low bioavailability. The objective of the present study…
Read More...
Read More...
AEROPERL® 300 Pharma – Improving the dissolution of poorly soluble APIs
AEROPERL® 300 Pharma colloidal silicon dioxide: Our solution to the solubility challenge
Active pharmaceutical ingredients (APIs) by Evonik in oral dosage forms need to dissolve before they can be absorbed in the intestine to enter the systemic circulation. Therefore, both the dissolution of…
Read More...
Read More...
Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
Read More...
Read More...
Pharmaceutical characterization and dissolution behavior of ibuprofen/Soluplus solvent cast films
Purpose: To characterize the physicochemical and dissolution properties of Soluplus®/ibupofen solid
dispersions prepared by solvent casting technique.
Methods: Soluplus® was used as a film-forming agent whereas ibuprofen served as a poorly soluble biopharmaceutics classification system (BCS)…
Read More...
Read More...