Pharma Excipients
Solids
Correlation between the powder characteristics and particle morphology of microcrystalline cellulose…
A quantitative approach is described to finding the correlation between the MCC application performance in tablets, which is key to pharmaceutical applications, and two kinds of powder features, 1) physical properties and 2) morphology, using multiple stepwise regression analysis to eliminate the…
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What’s next in the use of opacifiers for cosmetic coatings of solid dosage forms? Insights on…
The consolidated use of coatings containing E171 (i.e. titanium dioxide, TiO2) as an opacifier has made the white color of the resulting dosage forms a quality standard in the pharmaceutical and dietary supplement fields. This color is also associated with the efficiency of the coating layer in…
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Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive…
Purpose
Industrial implementation of continuous oral solid dosage form manufacturing has been impeded by the poor powder flow properties of many active pharmaceutical ingredients (APIs). Microfluidic droplet-based particle synthesis is an emerging particle engineering technique that enables the…
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Oxidation of Drugs during Drug Product Development: Problems and Solutions
Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder to control.
The propensity of a drug towards…
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Technology of Processing Plant Extracts Using an Aluminometasilicate Porous Carrier into a Solid…
A method of preparing tablets called liquisolid technique is currently emerging. In these formulations, an important role is played by porous carriers, which are the basic building blocks of liquisolid systems (LSSs). The most common are microcrystalline cellulose (MCC), magnesium…
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Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic…
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in…
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Towards Virtual Bioequivalence Studies for Oral Dosage Forms Containing Poorly Water-Soluble Drugs:…
The objective of the present study was to develop a physiologically based biopharmaceutics (PBBM) approach to predict the bioequivalence of dosage forms containing poorly soluble drugs. Aripiprazole and enzalutamide were used as model drugs. Variations in the gastrointestinal (GI) physiological…
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Investigating key properties of model excipients and binary powder blends using ultrasonic in-die…
In this work, the recently introduced Kilian Inline Measurement System (KIM) that enables ultrasonic measurements during powder compaction was studied using three pharmaceutical excipients with different properties and particle sizes, applying various amounts of lubricant and different compaction…
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Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid…
Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification method and optimized statistically by Box-Behnken design (3 factors at three levels BBD). Glyceryl…
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Breaking patterns of press-coated tablets during the diametral compression test: Influence of the…
Press-coated tablets are a high-interest technology in chronopharmaceutics, for modified release applications. As for any kind of tablet, the test of the mechanical resistance is of primary importance at the industrial level during both the development and production steps. For this purpose, the…
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