Pharma Excipients
Solids
Using Residence time distribution in pharmaceutical solid dose manufacturing – a critical review
While continuous manufacturing (CM) of pharmaceutical solid-based drug products has been shown to be advantageous for improving the product quality and process efficiency in alignment with FDA’s support of the quality-by-design paradigm (Lee, 2015, Ierapetritou et al., 2016, Plumb, 2005, Schaber,…
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Pseudo-3D Subsurface Imaging of Pharmaceutical Solid Dosage Forms Using Micro-spatially Offset…
A new combinatory Raman subtechnique of low-frequency and micro-spatially offset Raman spectroscopy (denoted micro-SOLFRS) is demonstrated via analysis of pharmaceutical solid dosage forms. A variety of different (multilayer/multicomponent) model systems comprising celecoxib, α-lactose (the…
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Development of Fully Redispersible Dried Nanocrystals by Using Sucrose Laurate as Stabilizer for…
There is much interest in converting poorly water-soluble drugs into nanocrystals as they provide extremely high surface area that increases dissolution rate and oral bioavailability. However, nanocrystals are prepared as aqueous suspensions, and once the suspensions are dried for development of…
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Towards a better understanding of thermally treated polycarbophil matrix tablets for controlled…
Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120–160 °C, POL shows interesting morphological modifications, related to changes in physical properties, such as swelling of…
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Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation…
Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles…
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Amorphous material: Definition and explanation by Pharma Drama
In this video Pharma Drama looks at the basic definition of an amorphous material - how they are defined, why they should really be considered as viscous liquids, and why they have different physical properties from crystalline materials.
Watch the video here:…
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Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification…
Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H1-antihistaminic activity…
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Lipid nanostructures for targeting brain cancer
Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these…
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3D Printing: an appealing technology for the manufacturing of solid oral dosage forms
Objectives
The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient’s needs. Three-dimensional printing (3DP) is an innovative emerging technology that can help to overcome these issues. The aim of…
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Formulation design, production and characterisation of solid lipid nanoparticles (SLN) and…
Lipid nanoparticles have been widely investigated for their use as either carriers for poorly water soluble actives or as (Pickering) emulsion stabilisers. Recent studies have suggested that the fabrication of lipid nanostructures that can display both these performances concurrently, can enable the…
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