Solids

A large number of dietary supplements are available in solid oral dosage forms. Vitamin and mineral supplements can be easily pressed into tablets by wet granulation or direct compression, but such tablet formulations require good binders. Commonly used binders in tablet formulations include…
Read More...

Hemp products are mostly sold in liquid form. Companies who are trying to change this and offer solid dose products have to face different challenges. The challenges depend on their choice of solid dosage form (tablets or capsules), technical requirements, their marketing strategy (color, legal…
Read More...

This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its…
Read More...

Commercial form: EUDRAGIT® E 100 Solid substance EUDRAGIT® E 100 is described in the monographs quoted above. EUDRAGIT® E PO Solid substance obtained from EUDRAGIT® E 100. EUDRAGIT® E PO is described in the Ph. Eur. and JPE monographs quoted above. The polymer conforms to the USP/NF…
Read More...

Developing a gastric resistant coating formulation can be quite demanding. There are a lot of interactions between polymer and active ingredient or non-functional excipients which have to be heeded. Even if all incompatibilities could be eliminated, the disintegration characteristics of the core…
Read More...

Evolution of the compaction properties of powders with the compaction speed (strain rate sensitivity, SRS) is a common phenomenon during the manufacturing of pharmaceutical tablets. Nevertheless, several different phenomena can be responsible of the SRS like friction, viscoelasticity,…
Read More...

The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as excipients. Pseudo-ternary phase diagrams were…
Read More...

The development of an efective oral therapeutics is an immediate need for the control and elimination of visceral leishmaniasis (VL). We exemplify the preparation and optimization of 2-hydroxypropyl-β-cyclodextrin (HPCD) modifed solid lipid nanoparticles (SLNs) based oral combinational cargo system…
Read More...

Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and to decrease dose frequency. The wet mass of the…
Read More...

Excipients with improved functionality have continued to be developed by the particle engineering strategy of co-processing. The aim of this study was to evaluate the compaction and tableting properties of composite particles of microcrystalline cellulose (MCC) and crospovidone (CPV) engineered by…
Read More...