Pharma Excipients
Solids
Model-dependent pharmacokinetic analysis of enalapril following the administration of novel…
Despite the legislative initiatives by the regulatory European medical agency (EMA) and the United States Food and Drug Administration Authority (FDA), an approved drug with child-appropriate dosage formulations are still absent for many drugs for pediatric heart failure. The pediatric patients are…
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Application of Supercritical Fluid Technology for Preparation of Drug Loaded Solid Lipid…
Small changes in pressure or temperature, close to the critical point, lead to large changes in solubility of supercritical carbon dioxide (CO2). Environmentally friendly supercritical CO2 is the most popular and inexpensive solvent which has been used for preparation of nanodrugs and nanocarriers…
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Problems during tablets manufacturing
Learn more about capping, lamination, picking and sticking as well as mottling, weight and hardness variations in tableting. All brought to to by Dr. Karim Maarif - founder of KMCD
Download the presentation here: some_basic_information_about_punches_tabletting_cycle__1581894721.pdf
Dr. Karim…
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Tableting of hot-melt coated paracetamol granules: Material tableting properties and quality…
Hot-melt coating (HMC) has been recognized as a promising technique in the production of solid dosage forms e.g., HMC of granules can be applied prior to compression in order to obtain modified drug release or taste masking. However, tableting properties of HMC granules have not been studied yet. In…
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Biopharmaceutical Understanding of Excipient Variability on Drug Apparent Solubility Based on Drug…
The presence of different excipient types/brands in solid oral dosage forms may affect product performance and drug bioavailability. Understanding the biopharmaceutical implications of superdisintegrant variability (changes in material properties), variation (changes in excipient amount) and…
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Monitoring lubricant addition in pharmaceutical tablet manufacturing through passive vibration…
In tablet manufacturing, a lubricant is added in a tumbling mixer prior to compression to ensure that the tablet is ejected smoothly without sticking or breakage. Control and monitoring of this process is critical as process parameters can negatively affect final tablet properties. Inline monitoring…
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Polymers for Extrusion‐Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process…
Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of ʹone size fits for allʹ. Using 3D printing, it is possible to design and develop complex dosage forms that can…
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A material-saving and robust approach for obtaining accurate out-of-die powder compressibility
Density is an important material property for evaluating, or developing a tablet formulation. In-die compressibility data can be obtained using a small amount of powder with the help of a compaction simulator. However, compacts undergo volume expansion upon ejection from die.
Therefore, accurate…
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A model to simultaneously evaluate the compressibility and compactibility of a powder based on the…
The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously. Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as CR = y0 + Ae−bP, r2 ≥ 0.9684 (where CR is the compression…
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Mechanistic aspects of drug loading in liquisolid systems with hydrophilic lipid-based mixtures
Despite the increasing interest in pharmaceutical use of mesoporous silica, there is still only limited knowledge on mechanisms of pore loading and subsequent drug desorption and release. Hence the aim of this work was to address the mechanistic aspects of drug loading into the mesoporous silica…
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