Pharma Excipients
Solids
Advantages and disadvantages of Hot Melt Coating
Advantages of Hot Melt Coating (HMC)
One advantage for the pharmaceutical industry is the simplification of complex dosage schemes, as several active ingredients can be combined, even those that cannot normally be combined. As the frequency of administration and complexity for users is reduced, the…
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The functionality of Hot Melt Coating
Guidance for an excellent Hot Melt Coating
Part 2 in the series of 3 articles
In order to reduce the problems of other solvent-based coating processes, such as time and cost intensity, the active ingredient coating by means of Hot Melt Coating (HMC) was developed.
HMC is a process in which…
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Why Hot Melt Coating?
Disadvantages of solvent-based coatings and why alternatives are needed
The coating of active substances requires the suspension of the auxiliary substances in a solvent. This mixture is then applied to the active ingredient particles. If water is involved, drying is required. This process is…
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Polymers and hydrogels to deter drug abuse – Engineering Drug Delivery Systems
In pharmaceutical formulations, polymers are traditionally and commonly used as viscosifier, binder, gelling agent, suspending agent, protective agent, controlled-release medium, adhesive, and packaging material.
With the development of the abuse-deterrent formulations in recent years, a new…
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Roller compaction
Roller compaction is the main technique employed in dry granulation.
Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally (through the ribbon thickness) or longitudinally (through the…
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Quantification of porogen effect on the drug release from single- and multi-layered ethylcellulose…
The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and…
A design of experiments (DOE) approach (2-level full factorial design) was used to investigate the effect of several formulation and process variables on the properties of fast disintegrating tablets comprising starch-based pellets and excipient granules and to optimize and validate the design…
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Continuous twin screw granulation: impact of binder addition method and surfactants on granulation…
Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the formulation aspect of these techniques, such as twin screw wet granulation, is still rather limited.
Previous research identified lactose/MCC/HPMC as a robust…
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Oral formulation strategies to improve the bioavailability and mitigate the food effect of…
Abiraterone acetate, marketed as Zytiga®, is an antiandrogen medication used in the treatment of prostate cancer. Abiraterone acetate is a BCS Class IV compound associated with several oral delivery challenges. Its low solubility and high lipophilicity lead to poor oral bioavailability (<10%) and…
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Solid Lipid Nanoparticles: A Multidimensional Drug Delivery System
The development of drug delivery carriers is often very challenging, due to the physicochemical properties of the drug such as poor solubility, low permeability, and short half-life. Development of colloidal delivery systems has introduced new avenues for safe and effective drug delivery. However,…
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