Pharma Excipients
Solids
A model to simultaneously evaluate the compressibility and compactibility of a powder based on the…
The present study aimed to establish a new model to evaluate the compressibility and compactibility of materials simultaneously.
Eighteen types of pharmaceutical excipients were studied via direct compaction. The model was established as CR = y0 + Ae- bP, r2 ≥ 0.9649 (where CR is the compression…
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Powder flow and mixing in different tablet press feed frames
Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets.
From Quality by Design (QbD) perspectives the feed frame plays a critical role and effects products critical…
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Investigation of the effects of particle size on fragmentation during tableting
Particle size is a critical parameter during tablet production as it can impact tabletability, flowability, and dissolution rate of the final product.
The purpose of this study was to investigate the effect of initial particle size on fragmentation of pharmaceutical materials during tableting.…
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Formulation and evaluation of new oxycodone extended release multiple unit pellet system
The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic,…
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Comparative dissolution studies on granules with acetaminophen and caffeine using the basket and…
Acetaminophen and caffeine, popular therapeutic substances used to relieve pain or alleviate the symptoms of cold.
The aims of the study were the comparison of granules, in terms of dissolution rate and moreover the development of spectrophotometric method to the simultaneous determination of…
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Effects of Compaction Pressure, Speed and Punch Head Profile on the Ultrasonically-Extracted…
Despite a well-established manufacturing-process understanding, tablet quality issues are frequently encountered during various stages of drug-product development.
Compact breaking force (tensile strength), capping and friability are among the commonly observed characteristics that determine the…
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Disruptive Materials – Pharma – presents a unique carrier for amorphous stabilization of poorly…
Located right in between Uppsala University, the Swedish Medical Products Agency and Uppsala University Hospital, the company is well positioned to exploit its pioneering discovery of a unique mesoporous magnesium carbonate (MMC) material. Up until breakthrough discovery by the group of professor…
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Taste masking of propranolol hydrochloride by microbeads of EUDRAGIT® EPO obtained with prilling…
The purpose of this study was to develop a new solid paediatric formulation for propranolol hydrochloride (PR).
This drug is used to treat various paediatric diseases, and recently received clearance to treat haemangioma. However, PR has a bitter salty taste that does not facilitate high rates of…
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Decoding the Small Size Challenges of Mini-tablets for Enhanced Dose Flexibility and Micro-dosing
Mini-tablets are an age appropriate dosage form for oral administration to pediatric and geriatric patients, either as individual mini-tablets or as composite dosage units.
Smaller mini-tablets than the commonly used 2 mm or larger size would offer added advantages to more tailored delivery of…
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Self-Micellizing Technology Improves the Properties of Ezetimibe and Increases Its Effect on…
The aim of this work was to develop ezetimibe self-micellizing solid dispersions using Kolliphor® RH40 (MS-K) as a surfactant incorporating ezetimibe (EZ) into the croscarmellose hydrophilic carrier.
Different ezetimibe:Kolliphor® ratios were studied to select micellar systems that improve the…
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