Pharma Excipients
Solids
Effects of process parameters of rotary tablet press on die filling behavior during mini-tablet…
This study focuses on the effects of process parameters of rotary tablet press on die filling behavior during the mini-tablet production.
Fill cam type, adjusted fill depth, and disc rotational speed were modulated, and mean tablet weight, mean powder fill level, and relative standard deviations…
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Development of dual–release pellets of the non-steroidal anti–inflammatory drug celecoxib
In the current study, once-a-day dual-release pellets of the selective non-steroidal anti-inflammatory drug celecoxib (200 mg) was developed to treat arthritis.
Pellets were prepared where a 100 mg celecoxib, located in the outer layer, was released in an immediate-release (IR) pattern, whereas…
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Relationship between compression pressure, mechanical strenghth and release properties of tablets
Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipi- ents.
Tablet production involves a series of unit operations in which drugs and excipients are subjected to mechanical stresses, such as compression pressure, thus imposing changes in the…
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Functionalized calcium carbonate based peptide formulation: aspects of the development for oral…
Diseases and malfunctions of the gastro intestinal tract belong to the most common illnesses in humans. This includes infections, caused by bacteria and fungi as well as food intolerances against a variety of dietary products. The prevalence of such diseases is increasing due to either bacterial…
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Solvent-free Hot Melt Extrusion Technique in Improving Mesalamine Release for Better Management of…
Poor oral bioavailability of mesalamine (Mes) is due to extensive metabolism in the intestinal epithelial cells in addition to the liver.
Purpose: Improved mesalamine release by Hot-Melt Extrusion (HME) technique could be utilized for better management of Inflammatory Bowel Disease (IBD).…
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Determinants of zero-order release kinetics from acetaminophen-layered Suglet® pellets,…
The potential for zero-order drug-release was evaluated for ethyl cellulose (EC) coated, acetaminophen-layered sugar pellets (Suglets®) of mesh size 18/20 (850–1000 μm).
To determine optimal plasticizer/pore-former concentrations for EC films, solvent-cast Aquacoat® ECD (ethyl cellulose…
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Study of Drug Particle Distributions within Mini-tablets Using Synchrotron X-ray Microtomography and…
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure a reliable, steady, and targeted release of the contained active pharmaceutical ingredients.
In this work, the drug particle distribution in mini-tablets was studied with synchrotron phase contrast…
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Formulation of Direct Compression Zidovudine Tablets to Correlate the SeDeM Diagram Expert System…
The SeDeM diagram expert system has been applied to study Zidovudine and some excipients. From the obtained diagrams, a pharmaceutical formula has been designed. SeDeM diagram ascertains the critical parameters that are suitable for a direct compression. The formula is compressed using a rotary…
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Native starch as in situ binder for continuous twin screw wet granulation
The use of native starch as in situ binder in a continuous twin screw wet granulation process was studied.
Gelatinization of pea starch occurred in the barrel of the granulator using a poorly soluble excipient (anhydrous dicalcium phosphate), but the degree of gelatinization depended on the…
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Future Perspectives for Patient-Centric Pharmaceutical Drug Product Design with Regard to Solid Oral…
In current days, the majority of healthcare systems across the industrialized countries are facing global challenges. These challenges are related to the constantly increasing costs of basic healthcare provision, with no optimal improvements in the level of care provided to the patients.
The…
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