Pharma Excipients
Solids
Oral Insulin – Microneedle patch drug delivery in the gut
A novel oral capsule can deploy microneedle patches that release drugs into the intestinal wall for uptake into the bloodstream as shown in animal studies, thereby avoiding injections.
Patients dislike shots and often cannot self-administer them. Therefore, doctors are frequently hesitant to…
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Formulation, Development and Scale-Up of Fixed-Dose Combination Tablets Containing Zidovudine,…
The development of antiretroviral associations in a single dosage form aims to ensure good efficacy, low costs and better adherence to treatment.
Thereby, this work aimed to perform the pharmacotechnical development and stability studies of coated tablets of fixed-dose combination of zidovudine,…
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Colon Drug Delivery Systems for the Treatment of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is one of the most common chronic diseases that affect the entire gastrointestinal tract (GIT) especially the colon.
Its symptoms extend from mild diarrhea, abdominal pain, and bloody diarrhea to severe conditions which affect the quality of life. Many treatments…
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Influence of mesoporous silica on powder flow and electrostatic properties on short and long term
Flow aid additives are commonly used in industries to improve the processing of cohesive powders.
A wide variety of additives are available: magnesium or calcium stearate, fumed and mesoporous silica, talc, etc. The efficiency of the additive depends on the cohesive forces playing a role in the…
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Synthesis and characterization of acetyl curcumin-loaded core/shell liposome nanoparticles via an…
Despite substantial advancements in divergent drug delivery systems (DDS), there is still room for novel and innovative nanoparticle-mediated drug delivery methodologies such as core/shell liposomes to deliver drugs in a kinetically controlled manner into the active site without any side effects.…
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Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and…
Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release.
With this in view, we aimed at achieving furosemide’s longer gastric retention and…
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DOE Case Studies for Industrial Applications
An integrated approach based on QbD and PAT provides a systematic and innovative framework for product development, manufacturing, and quality risk management.
In this context, the significance of the outcome of design of experiments (DOEs) to the selection of the product design, robust…
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Applications of mesoporous material for drug delivery
In recent years mesoporous silica is gaining attention because of their emerging applications in drug delivery.
Since their first appearance in materials science in the 1990s, these inorganic carriers have been successfully used in other areas such as catalysis, purification, and adsorption. The…
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Microdosed midazolam in a buccal film
Cytochrome P450 3A (CYP3A) isozymes metabolize about 50% of all marketed drugs. Their activity can be modulated up to 400-fold, which has great impact on individual dose requirements for CYP3A substrates. The activity of CYP3A can be monitored using the CYP3A substrate midazolam. To avoid…
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An Update of Moisture Barrier Coating for Drug Delivery
Drug hydrolytic degradation, caused by atmospheric and inherent humidity, significantly reduces the therapeutic effect of pharmaceutical solid dosages.
Moisture barrier film coating is one of the most appropriate and effective approaches to protect the active pharmaceutical ingredients (API) from…
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