Pharma Excipients
Solids
Comparison of the coating process and in vitro dissolution of 3 mm gastro-resistant minitablets and…
Minitablets are solid oral forms, which, due to their size (1-3 mm), may be easily swallowed by children.
The administration of minitablets in a certain number of units allows for flexible dosing for a broad age group of paediatric patients, which is particularly important for modified-release…
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Taste masked natural caffeine
The bitter taste of caffeine can be a challenge especially in orally dispersible or liquid dosage forms. In both cases a taste masking by coating or encapsulation of the caffeine can be an effective way to achieve the desired result and increase the acceptance of the final product.
Micro…
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Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant…
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
To this purpose, solid lipid microparticles (SLMs) with Dynasan 114 and a mixture of Dynasan 114 and Dynasan 118…
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Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance…
The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release.
Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of…
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Dissolution is beautiful – see the wonders of dissolution with new eyes
Testing of pharmaceutical dosage forms can be beautiful!
SOTAX took a closer look at what happens to tablets and capsules when they disintegrate/dissolve and release their API during dissolution tests - and the results are stunning.
Every day thousands of dissolutions tests are performed in…
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The subdivision behavior of polymeric tablets
The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study.
The polymeric tablets were submitted to different post-treatments (aging,…
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Huperzine a loaded multiparticulate disintegrating tablet
Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing.
The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs). F127 was added to facilitate drug release of EC MPs, and the…
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Inkjet printing of solid oral dosage
Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate, followed by solidification. This process can potentially be used to address limitations for the manufacturing of solid oral dosage forms or tablets. Conventional processes can be…
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Solidifying ticagrelor loaded self-microemulsifying drug delivery system
The aim of this study was to solidify a ticagrelor loaded self-microemulsifying drug delivery system (TCG-SM) with enhanced dissolution and bioavailability of ticagrelor (TCG) for developing TCG-SM granules and tablets.
TCG was dissolved in the self-microemulsifying drug delivery system (SMEDDS)…
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Towards Printed Pediatric Medicines in Hospital Pharmacies
To date, the lack of age-appropriate medicines for many indications results in dose manipulation of commercially available dosage forms, commonly resulting in inaccurate doses.
Various printing technologies have recently been explored in the pharmaceutical field due to the flexible and precise…
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