Pharma Excipients
Solids
Screening of different polysaccharides in a composite film based on Eudragit RS for subsequent use…
This study aims at identifying the more suitable polysaccharide in a composite film based on Eudragit RS for 5-ASA delivery to the colon.
Different polysaccharides (pectin, chitosan, guar, inulin, and dextran) were examined. The mechanical properties, swelling index, loss of film mass and…
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In-line monitoring of powder blend homogeneity in continuous drug manufacture using near infrared…
The pharmaceutical industry faces technical challenges in the near future when transitioning from the traditional batch wise manufacturing to continuous manufacturing.
One issue that needs to be solved is how to obtain high-quality measurements of a moving solid powder sample. The aim of this…
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Liqui-Pellet: the Emerging Next-Generation Oral Dosage Form Which Stems from Liquisolid Concept in…
In spite of the major advantages that the liquisolid technology offers, particularly in tackling poor bioavailability of poorly water-soluble drugs (i.e., BCS Class II drugs), there are a few critical drawbacks.
The inability of a high liquid load factor, poor flowability, poor compactibility,…
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Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and…
The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility. Furthermore, new chemical entities are even less soluble compared to marketed…
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Novel Hot Melt Extruded Matrices of Hydroxypropyl Cellulose and Amorphous Felodipine–Plasticized…
Hydroxypropyl methylcellulose (HPMC) is a hydrophilic retarding-release polymer with the limited application in hot melt extrusion (HME) due to its high glass transition temperature (Tg181–191°C) and melt viscosity.
The aim of this study is to develop hot melt extruded matrices using…
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Application of lactose in the pharmaceutical industry
This chapter describes the application of lactose as excipient in the pharmaceutical industry. About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of the biggest pharmaceutical excipients.
Lactose can have several functions in a dosage form: as a filler to…
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Development and evaluation of an omeprazole-based delayed-release liquid oral dosage form
Modified-release oral dosage forms are commonly used in pharmaceutics to delay or sustain the release of drugs. Nowadays, they are only marketed as solid dosage forms such as capsules or tablets.
Therefore, the development of a liquid oral dosage form with modified-release properties has been…
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Study of the critical points in combined matrix tablets containing both inert and swelling…
This work estimates for the first time critical points in combined matrices containing varying concentrations of the hydrophilic polymer Hydroxypropyl methylcellulose (HPMC) K100 M CR in presence of a constant percentage of the inert matrix forming polymer Eudragit RS-PO as well as varying…
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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying…
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Thermoplastic polyurethane as matrix forming excipient using direct and ultrasound-assisted…
Thermoplastic polyurethanes (TPU) are block copolymers utilized in a wide variety of applications due to their superior characteristics as resistance, flexibility and biocompatibility. However, the use of TPU as a matrix tablet forming excipient is more limited.
For the first time, matrix tablets…
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