Solids

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where thermodynamics, polymer screening, multivariate statistics and process optimization are combined, to increase the success of…
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Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract Peptides are rarely orally administrated due to rapid degradation in the gastrointestinal tract and low absorption at the epithelial border. The objective of this study was to encapsulate…
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Increasing tensile strength by reducing particle size for extrudate-based tablet formulations The effect of milled extrudate particle size on tablet tensile strength was investigated in this study. Parameters used for milling with a hammer impact mill were investigated to give different particle…
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Structure reinforcement of porous hydroxyapatite pellets using sodium carbonate as sintering aid: Microstructure, secondary phases and mechanical properties Porous HAP pellets suitable for loading therapeutic agents were prepared using microcrystalline cellulose (MCC) as pore former and sodium…
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Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition Alginate beads are commonly used for protection of probiotics against adverse environmental conditions. However, alginate beads are unable to provide complete cell viability under stringent…
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Design and 3D printing of multi-compartmental PVA capsules for drug delivery 3D printing is predicted to play a significant role in the future of the pharmaceutical industry. Personalized drug delivery, which includes personalizing dosage forms, drug content and release has become a new,…
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Solidification of carvedilol loaded SMEDDS by swirling fluidized bed pellet coating Self-(micro)emulsifying drug delivery systems (S(M)EDDS) have emerged as effective vehicles for enhancing bioavailability of poorly water soluble drugs, however solidification of the systems represents a major…
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Percolation theory provides a statistical model which can be used to predict the behaviour of powder blends based on particle-particle interactions. The aim of this study was to investigate if percolation theory could be used to predict the drug loading concentration of pharmaceutical tablets, and…
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Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol…
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Mannitol and lactose are commonly used fillers in pharmaceutical tablets, available in several commercial grades that are produced using different manufacturing processes. These grades significantly differ in particulate and powder properties that impact tablet manufacturability. Choice of…
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