Pharma Excipients
Solids
Correlation between the solid state of lipid coating and release profile of API from hot melt coated…
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors for application of HMC for industrial productions.
In this…
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A QCM-based assay of drug content in Eudragit RS 100-based delivery systems
A specific version of the quartz crystal microbalance method has been proposed for quantitative evaluation of drug content in polymeric drug carrier systems. In this study, ammonio methacrylate copolymer (type B) microparticles and their standard solutions have been prepared and loaded with set…
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Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a…
In the current study, the ability to use in-line NIR inside the feed frame of a tablet press to monitor the residence time distribution inside the tablet press was investigated.
Pulse-response experiments were performed. In-line measurements inside the feed frame were compared to measurements on…
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Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to ensure quality of tablets.
In this study, for ibuprofen…
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Drug delivery through wafer technology: Formulation and manufacturing of buccal and oral…
A great number of patients have difficulty swallowing or needle fear. Therefore, buccal and orodispersible dosage forms (ODFs) represent an important strategy to enhance patient compliance. Besides not requiring water intake, swallowing or needles, these dosage forms allow drug release modulation.…
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Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique
Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs.
The objective of the present study was to develop a…
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Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems
Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems.
Particles are an important part of many dosage forms and viewed as…
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Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a…
As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively poor water solubility and permeation in vivo. In the study, we developed novel solid dispersions (SD) of LPV to improve its bioavailability and to describe their overall behaviors.
By employing solvent…
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“From Powders to Agglomerates” an Overview on Process Technologies and characteristics of the…
Download the Poster or order a Hard Copy (Format Din A0) here
The poster "From Powders to Agglomerates" gives an overview on the different process technologies and processing steps involved for each technology. It also shows the characteristics of the granules including porosity, bulk density, etc.
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Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
This thesis has focused on the study of pharmaceutical cocrystal production, and the impact of introducing an excipient into the manufacturing process. Cocrystals of sulfadimidine (SDM) and 4-aminosalicylic acid (4ASA) were formed in the presence of an excipient by spray drying and spray coating,…
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