Pharma Excipients
Solids
Processability of AquaSolve™ LG polymer by hot-melt extrusion
The objective of this study was to investigate the processability of AquaSolve™ hydroxypropyl methylcellulose acetate succinate L grade (HPMCAS LG) via hot-melt extrusion and to examine the effect of pressurized carbon dioxide (P-CO2) on the physicomechanical properties of efavirenz (EFA)-loaded…
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Solid lipid particle-based tablets for buccal delivery
This study aims to develop mucoadhesive tablets containing solid lipid particles for controlled release pattern through buccal delivery. The buccal tablets containing drug-loaded solid lipid particles (SLPs) were fabricated using the ultrasonication method and lyophilisation with the incorporation…
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Adjustment of triple shellac coating for precise release of bioactive substances with different…
Formulations for the controlled release of substances in the human terminal ileum and colon are essential to target the gut microbiome and its interactions with the intestinal mucosa. In contrast to pharmaceutical enteric coatings, reliable food-grade alternatives are still scarce.
Shellac…
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Two-component cross-linkable gels for fabrication of solid oral dosage forms
Current three-dimensional (3D) printing techniques involve the solidification of the injected materials by means of UV irradiation, evaporation of organic solvents, or harsh heating and cooling processes. These methods limit the printing of many sensitive bio-active molecules such as proteins.
We…
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Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of…
Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is a major challenge due to technical and quality constraints.…
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Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug…
Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of the active pharmaceutical ingredient and its transport across the gut wall.
The efficiency of these processes is…
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Characterisation of mini-tablets – Pediatrics
Mini-tablets are a pharmaceutical dosage form with a diameter of typically ≤ 3 mm. This is a potential dosage form for pediatrics since the small size of mini-tablets can ease the swallowing of medicines. In recent years there has been an increasing demand for research and development concerning…
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Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted…
Ultrasound assisted compression (USAC) is a manufacturing technique which applies thermal and mechanical energy to the powder bed, producing tablets with improved characteristics compared to the direct compression process. This technology is ideal for thermoplastic materials, as polyurethanes, whose…
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of…
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Ultra–fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive
Orodispersible tablets (ODTs) are a convenient dosage form and a recent trend in formulation development. The fast disintegration is accompanied by rapid removal of the active principle and the excipients from the mouth due to saliva flow and swallowing.
Probiotic bacteria are a promising…
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