Solids

If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration. How to obtain sustained release tablets of metformin hydrochloride by direct compression? The aim was to develop dual SR…
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Oral Thin Film (OTF) is a newly emerging drug delivery system which has many benefits for patients. Although there has been some formulation of OTF products, these have mainly been as confectionary or dental health products. The most significant benefit of this dosage format will only be realised…
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The multiparticulate drug product concept covering micropellets, pellets,and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with…
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3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found widespread industrial applications for production from…
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Due to fast growth of clean label movement, the term natural colour was defined by “Regulation (EC) No 1333/2008” which explains the detailed rules on the use of food additives. This regulation was updated in 2010 (Commission Regulation 257/2010) and established a program for re-evaluation of…
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To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but…
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The aim of the current study is to optimize the bed fluidized coating process of mini tablets by means of an acoustic levitator. The optimized coating parameters, which have to be set in a fluidized bed reactor, can be determined by means of contactless levitation of a single mini tablet in an…
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The purpose of the study was to develop sustained release tablets containing bisoprolol fumarate and an innovative combination of Precirol ATO5 and hydroxypropyl methylcellulose, in order to conclude upon: properties of pharmaceutical tablet formulations, drug-excipients interactions, evaluate their…
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Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes. In the present study, pellet coating process was monitored using four different PAT approaches, i.e. near-infrared (NIR) spectroscopy, Raman spectroscopy, in-line…
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Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there is growing evidence for an increasing prevalence of impaired…
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