Pharma Excipients
Solids
Solid nanoparticles for oral antimicrobial drug delivery: a review
Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this…
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HiCel™ Silicified Microcrystalline Cellulose
HiCel™ is a versatile co-processed excipient with added-value to standard microcrystalline cellulose types. See this short video to get an overview of why you should consider HiCel™ in your formulation work:
Click here for more information on Sigachi´s excipients!
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Abuse Deterrent Immediate Release Egg-Shaped Tablet (Egglets) Using 3D Printing Technology
Opioid abuse is a growing problem and has become a national health crisis over the past decade in the USA. Oral ingestion, snorting, and injection are the most commonly employed routes of abuse for an immediate release product. To circumvent these issues, we have developed an egg-shaped tablet…
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Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally…
Orally disintegrating tablets (ODTs) attract a great attention as this easy swallowing dosage form often improves patient compliance. In the current work, orally disintegrating tablets comprising mannitol, polyvinylpyrrolidone (PVP) and an amino acid (alanine, glycine or serine) with various…
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Design, formulation and manufacture of film-coated drug products
Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation strategy and to modify or delay drug release.
The film coat,…
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Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by…
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Interpolymer complexes of Carbopol® 971 and poly(2-ethyl-2-oxazoline): physicochemical studies of…
Carbopol® 971 and poly(2-ethyl-2-oxazoline) form hydrogen-bonded interpolymer complexes in aqueous solutions and their complexation is strongly dependent on solution pH. This work investigated the complexation between these polymers in aqueous solutions. The compositions of interpolymer complexes as…
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What are pharmaceutical film coatings? Part 1 -Tablets
There a many reasons for coating of different pharmaceutical products such as pellets, granules, capsules, powders and crystals. In this article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets is a complex process that results in the forming of a thin layer…
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Non-traditional application of drug and excipient
During formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role. One of the examples of a non-traditional role is of a drug acting as a plasticizer. Plasticization tendency of APIs on polymers can be advantageous for…
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Lipids and polymers in pharmaceutical technology: lifelong companions
In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and…
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