Pharma Excipients
Solids
Novel Dissolution Method for Oral Film Preparations with Modified Release Properties
Oromucosal film preparations have gained popularity in pharmaceutical research and development. Therefore, oral films have been integrated into the monograph “oromucosal preparations” of the European Pharmacopeia in 2012. Regulatory authorities explicitly demand dissolution studies for films, but…
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Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation
Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric…
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Evaluation of calcium magnesium silicate-date palm cellulose as a potential tablet excipient
A new excipient was prepared using natural resources and bio-wastes such as sodium silicate, brine and date palm cellulose. The prepared excipient is water-insoluble silicate salt precipitated in date palm cellulose (WISS-DPC). The aim of this study was to evaluate the potential use of this new…
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Impact of material properties and process variables on the residence time distribution in twin screw…
Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the…
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Individualized in vitro and in silico methods for predicting in vivo performance of enteric-coated…
The efficacy of narrow therapeutic index (NTI) drugs is closely related to their plasma concentration-time profile. Particularly for these compounds interindividual variability of gastrointestinal (GI) parameters relevant to in vivo drug release may result in fluctuations of the plasma…
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Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the…
The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for…
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Probing the impact of HPMC viscosity grade and proportion on the physical properties of…
This study investigated the impact of hydroxypropyl methylcellulose (HPMC) viscosity grade, HPMC proportion and particle size fraction on the physical properties of the freeze-dried mannitol-HPMC excipients produced, using multivariate analysis methods. Solutions containing 20 %, w/w mannitol-HPMC…
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Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures?
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug diffusion rates achieved by varying hydrophilic-to-hydrophobic…
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Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult formulations, but medication errors can result in suboptimal efficacy…
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Solidification to Improve the Biopharmaceutical Performance of SEDDS: Opportunities and Challenges
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid…
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