Pharma Excipients
Solids
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its stability after 3-month storage at 40°. Lactose-containing…
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A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing
A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar, shape retainability, and compressive strength of extruded SAC…
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Liquisolid Systems: Understanding the impact of drug state (solution or dispersion), nonvolatile…
The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an important role in the dissolution and absorption phenomenon.…
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Hybrid modeling of roll compaction processes with the Styl’One Evolution
Roll compaction/dry granulation is a widely used and cost effective dry granulation method. To save time and material in formulation development, some approaches have been made to predict the most important parameters in roll compaction (RC) like gap width, specific compaction force (SCF) and ribbon…
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A Big Data Approach to Pharmaceutical Flow Properties
Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need to better understand and share the typical flow properties…
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A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the implications of the choice of excipients on the dissolution of…
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Amorphous multi-system of celecoxib improves its anti-inflammatory activity in vitro and oral…
In the present study, a multi-system for solid dispersion (SD) of celecoxib (CXB) was designed to improve its solubility and anti-inflammatory effects in vitro as well as oral absorption in rats. The SD formulations were prepared by a solvent evaporation with a multi-system as the solubilizer; an…
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Testosterone- and vitamin-grafted cellulose ethers for sustained release of camptothecin
Camptothecin (CPT), a potent anticancer drug with known antiviral activity, is halted of clinical use. Few drug delivery systems of CPT are approved for therapy. Hereby, we propose the encapsulation of hydrophobic CPT in the inner core of cellulose nanoaggregates for sustained release with retaining…
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The Application of Machine Learning Algorithms in Understanding the Effect of Core/Shell Technique…
This study systemically investigated the application of core/shell technique to improve powder compactability. A 28-run Design-of-Experiment (DoE) was conducted to evaluate the effects of the type of core and shell materials and their concentrations on tensile strength and brittleness index. Six…
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Excellence in Lactose
In this video you learn more about Armor Pharma's Lactose production and solutions offered.
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