Pharma Excipients
Solids
3D printing for chemical, pharmaceutical and biological applications
3D printing is becoming increasingly prevalent in modern chemistry laboratories. This technology provides chemists with the ability to design, prototype and print functional devices that integrate catalytic and/or analytical functionalities and even to print common laboratory hardware and teaching…
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Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid…
3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is approved on the US market. The medicine is manufactured via…
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Solid Oral Dose Process Validation
Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3). Recent regulatory guidance's such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. The concepts are now harmonized across regulatory guidance's and organizations have an…
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Pediatric Oral Formulations: An Updated Review of Commercially Available Pediatric Oral Formulations…
Oral pediatric formulations are either ready-to-use or require manipulation, and multi-use or single-use. Strong encouragement for preservative-free pediatric formulations has resulted in fewer multi-use solutions or suspensions in favor of single-use solid oral dosage forms. This updated review…
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Direct compression tablet containing 99% active ingredient – a tale of spherical crystallization
Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, since it only involves blending and compression. However, active pharmaceutical ingredients (API) generally exhibit poor mechanical and micromeritic properties, which necessitate dilution and the use of…
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Conversion of PLGA nanoparticle suspensions into solid dosage forms via fluid bed granulation and…
Incorporating poorly soluble drugs into polymeric nanoparticles is a widely investigated approach to improve their biopharmaceutical performance. Poly(DL-lactide-co-glycolide) (PLGA) nanoparticle formulations have previously been tested and recommended as drug carriers for peroral administration of…
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Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles
Epilepsy is the most common chronic brain disorder and affects millions of people worldwide. Carbamazepine (CBZ) is one of the first-line pharmacological therapy instituted to patients due to its wide spectrum of action. Although marketed for more than 30 years, CBZ efficacy is strongly limited by…
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Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release tests using three different set-ups: the Franz cell, the…
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Effects of Different Polymers on Thermal Inkjet Printing of Oral Thin Films: A Novel Approach
The aim of this research was to use inkjet printing technology in formulation of personalized medicine. Thus in this research, an attempt was made to print OTF by TIJ printing. A placebo solution comprising of different polymers and polymer concentrations was used for TIJ printing on A4 paper. The…
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