Pharma Excipients
Solids
Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based…
The absolute bioavailability of many small molecule kinase inhibitors (smKIs) is low. The reasons for low bioavailability are multifaceted and include constraints due to first pass metabolism and poor absorption. For smKIs where absorption limits oral bioavailability, low aqueous solubility and high…
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Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid…
Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the conventional melting or solvent-evaporation methods.…
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Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets
Prolonged drug release provided by multiple-unit dosage forms is highly beneficial to enhance the compliance and safety of the pharmacotherapy even for patients with swallowing deficiencies. To facilitate the intake for these patients, multiple-unit tablets and capsules have to be crushed or opened.…
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Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in…
Anti-HIV drug Lamivudine exhibit shorter half-life (2 h) and poor bioavailability (62% in paediatric patients), multiple dosing is required. To overcome the limitations, nanoparticles loaded buccal film was developed for prolonged drug release and improved efficiency. Nanoprecipitated…
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Guar gum: Versatile natural polymer for drug delivery applications
Guar gum a non-ionic polysaccharide obtained from the seeds of Cyamopsis tetragonolobus of the Leguminosae family is found abundantly in nature. It finds extensive use in a variety of fields such as food industry, textile industry, paper industry, cosmetic industry, pharmaceutical industry among…
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Granulation techniques and technologies: recent progresses
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine powders into free-flowing, dust-free granules that are easy…
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A Novel Complex of Chitosan–Sodium Carbonate and Its Properties
Chitosan has excellent properties, as it is nontoxic, mucoadhesive, biocompatible, and biodegradable. However, the poor water solubility of chitosan is a major disadvantage. Here, a novel chitosan-sodium carbonate complex was formed by adding a large amount of sodium carbonate to a chitosan/acetic…
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Efficient Mucosal Immunization by Mucoadhesive and pH-Sensitive Polymeric Vaccine Delivery System
Mucosal surfaces as the largest immune organ of human body cover 400 m2 of the body including the gastrointestinal, urogenital, and respiratory tracts. The local mucosal immunity is an important first line of defense against many pathogens because most pathogens initiate their infection through…
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Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters
Abstract Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses (granules), in which the original particles are still identifiable. In wet granulation processes, the powder particles are aggregated through the use…
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