Solids

Alkindi® is a novel oral multi-particulate taste-masked formulation of hydrocortisone for use in children with the rare disease adrenal insufficiency. The objective of the present work was to study the biorelevant dissolution and compatibility properties of Alkindi® granules following…
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Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the…
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Data from wall friction testing and physical property characterization of over one hundred pharmaceutical powders, blends, and granulations has been analyzed. The analyses focused on data for stainless steel surfaces with the most common finishes for pharmaceutical powder processing equipment,…
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Lipid coating in a high shear blender without heating and complex spray mechanism was investigated as a simplified approach to hot melt coating in a fluid bed device. Potassium chloride was coated with 20% glyceryl distearate using both processes. Microscopic images revealed that the drug surface…
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We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable polymethacrylic anhydride (PMAH) coating. The coating was synthesized via a mild vapor polymerization…
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The causes of atypical nitrogen adsorption isotherm features of commercial magnesium stearate grades have been investigated through a combination of alternative adsorbates and variation of analytical conditions. Atypical features have previously been identified as having poor linearity of adsorption…
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Increasing patient adherence to medication regimens remains a top priority in the pharmaceutical industry. Simultaneously, consumers/patients are looking for dosage forms that are easy to take and that will not disrupt their everyday “on the go” lifestyle. Orally disintegrating tablets (ODTs) can…
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Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool for monitoring pharmaceutical film-coated tablets. OCT…
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In this video Chris Moreton gives an interesting insight on pharmaceutical excipients. 
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Three-dimensional printing (3DP) is also known as additive manufacturing because these technologies create a part by adding material layer by layer, guided by a 3D computer model. Various types of 3DP are being used in manufacturing in industries ranging from aerospace to medical devices, and some…
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