Pharma Excipients
Solids
Just a spoonful of… makes the medicine go down.
galenIQ™ is a soluble filler-binder characterized by its ease of use and applicability to a wide range of solid and liquid medicine such as tablets, sachets, lozenges and syrups. The main reason it works is its delicate sweetness. Read more about the application and key benefits of galenIQ™ on our…
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Rheology of Cellulose Ether Excipients Designed for Hot Melt Extrusion
new family of cellulosic ether polymeric excipients has been recently engineered for fabrication of amorphous solid dispersions (ASDs) of active pharmaceutical ingredients (API) via hot-melt extrusion (HME). These hydroxypropyl methyl cellulose (HPMC) excipients enable plasticizer-free melt…
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Dissolution improvement of an active pharmaceutical ingredient in a polymer melt by hot melt…
Dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in polymeric melts plays an important role in the manufacturing of solid dispersions and solid solutions. The understanding of the dissolution is essential for selecting the processing equipment, the operating conditions,…
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A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the implications of the choice of excipients on the dissolution of…
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Review Oral Modied Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and…
Oral modied-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated multiparticulates into tablets to produce a sustained-release dosage form…
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Physical and rheological properties of xanthan gum agglomerated in fluidized bed: Effect of HPMC as…
Physical and rheological properties of agglomerated xanthan gum (XG), commonly used as a food thickener for the management of the patients with dysphagia (swallowing difficulty), were investigated at different concentrations (0, 2, 4, and 6% w/w) of hydroxypropyl methylcellulose (HPMC) as a binder…
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Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution…
We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ), a poorly soluble drug, and its dissolution from spray-dried suspensions. To this end, ITZ suspensions with SSL, SL, and L grades of hydroxypropyl cellulose (HPC)…
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Effect of Binder Attributes on Granule Growth and Densification
The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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Orally disintegrating dosage forms
What is an orally disintegrating dosage form?
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many…
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Orally disintegrating dosage forms
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many advantages. Many studies have compared this form of…
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