Pharma Excipients
Solids
Investigate the Effect of Solvents on Wet granulation of Microcrystalline Cellulose
12. February 2018
Introduction
Since decades, granulation is operational as a critical size enlargement process for powder agglomeration in tablet manufacturing. Dry granulation , melt granulation and wet granulation are some of the most common techniques utilized…
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3D printed devices in the gastrointestinal tract of rodents – imaging by PET/CT
04. December 2017
Abstract
Fused deposition modelling (FDM) 3D printing (3DP) is a revolutionary technology with the potential to transform drug product design in both the pre-clinical and clinical arena. The objective of this pilot study was to explore the intestinal behaviour…
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EXCIPIENT REQUIREMENTS IN THE FORMULATION OF SOLID ORAL DRUG FORMS
A Capsugel paper on the search for physiologically unobjectionable coloring agents for pharmaceutical drug formulations in capsules. Comparative analysis between the caplet and capsules wherecapsules are shown to shorten development times.
Excipient requirements in the formulation of solid oral…
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A retrospective and observational analysis of harmful excipients in medicines for hospitalised…
13. March 2017
Background Medicines used in neonates contain different excipients, which may not be safe in this age group.
Objective To analyse the frequency at which hospitalised neonates are exposed to harmful excipients (HEs) and to identify substitution possibilities for…
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An update on electrostatic powder coating for pharmaceuticals
19. January 2017 Abstract Derived from dry powder coating of metals, electrostatic powder coating for pharmaceuticals is a technology for coating drug solid dosage forms. In this technology, coating powders, containing coating…
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Engineering hot-melt extruded solid dispersion for controlled release of hydrophilic drugs
Abstract
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via…
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Microencapsulated SLN: An innovative strategy for pulmonary protein delivery
Abstract
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low…
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Complication with Order: Understanding the Structure-Property Relationship of Polymers for their…
09. November 2016
Complication with Order: Understanding the Structure-Property Relationship of Polymers for their Application in Drug Delivery
In modern pharmaceutical dosage form design, excipients play a central role in delivering the drug in a safe and effective manner.…
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Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing
25. June 2016
Abstract
Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However, most API powders are fine and cohesive and not processable by hot-melt coating. The aim of this study was to produce…
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A MALLEABLE TECHNIQUE FOR FUTURE COATING PROCESS–SOLVENTLESS COATING
06. April 2016 Coatings are a vital part in the formulation of pharmaceutical dosage form to attain grander aesthetic quality, physical and chemical protection for the drugs in the dosage forms, and modification of drug release…
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