Pharma Excipients
Solids
A MALLEABLE TECHNIQUE FOR FUTURE COATING PROCESS–SOLVENTLESS COATING
06. April 2016 Coatings are a vital part in the formulation of pharmaceutical dosage form to attain grander aesthetic quality, physical and chemical protection for the drugs in the dosage forms, and modification of drug release…
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13C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug…
Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters. Therefore, experimental parameters like contact time of cross-polarization and repetition time have a major impact on the registered solid state NMR spectra and in…
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Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion
The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the water insoluble indomethacin (INM), co-processed by hot melt extrusion (HME). Formulations consisted of the hydrophilic hydroxypropyl methyl cellulose polymer (HPMCAS) and stearoyl…
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Nanostructured lipid carriers: An emerging platform for improving oral bioavailability of lipophilic…
21. October 2015
Nowadays exploration of novel lipid-based formulations is akin to a magnet for researchers worldwide for improving the in vivo performance of highly lipophilic drugs. Over the last few years, new compositions of lipids have been developed, and the probable…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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FORMULATION DEVELOPMENT – A QbD Approach to Develop Extended Release Softgels
31. March 2015
Soft gelatin capsules (softgels) continue to be the oral solid dosage form preferred by consumers.1 Understandably, as they are easy to swallow and digest, effectively mask unpleasant tastes and smells, and have a pleasing appearance. Softgels also offer formulation and marketing…
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