Pharma Excipients
Solids
Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin…
l-ascorbic acid (Vitamin C, VC)is the most abundant antioxidant in human skin. But its poor penetration into the skin and unstability limit the application. The aim of the study was to promote the topical skin permeation and retention of VC, increase the stability as well as effectiveness by a novel…
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Early Detection and Assessment of Invisible Cracks in Compressed Oral Solid Dosage Forms
In the pharmaceutical manufacturing industry, real-time in situ quality monitoring for detecting defects at an early stage is a desirable ability, especially in high-rate production, to minimize downstream quality-related issues, financial losses, and timeline risks. In this study, we focus on the…
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Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a…
The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt…
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Ocular Drug Delivery: a Comprehensive Review
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration is an interest of scientists for many decades. Their difficult mission is to prolong drug residence time and guarantee an…
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Enhancement of itraconazole solubility and release by hot-melt extrusion with Soluplus®
Formulation of poorly water-soluble drugs is a significant challenge in the development of oral solid dosage forms. The objective was to investigate the effect of hot-melt extrusion process and formulation variables on the solid state, solubility and release of an ionizable poorly soluble drug,…
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The Significance of Tablet Internal Structure on Disintegration and Dissolution of Immediate-Release…
The internal microstructure of a tablet, such as pore geometry and pore volume, impacts the tablet’s disintegration kinetics. Ideally, one could design the microstructure to control dissolution onset and therapeutical performance of immediate-release formulas; however, manufacturing tablets with a…
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Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet…
Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is difficult to scale up drug product manufacturing. Injection molding has been used in conjunction with hot-melt extrusion to mass produce drug products, but making…
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Fabrication of Sustained Release Curcumin-Loaded Solid Lipid Nanoparticles (Cur-SLNs) as a Potential…
The goal of current research was to develop a new form of effective drug, curcumin-loaded solid lipid nanoparticles (Cur-SLNs) and test its efficacy in the treatment of lung cancer. Different batches of SLNs were prepared by the emulsification–ultrasonication method. For the optimization of…
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Tackling the Trends – How Excipient Technologies Enable Oral Solid Innovation
Did you know that between 2015 and 2019, 70% to 80% of new molecular entities (NMEs) approved by the FDA were small molecules, and, in 2019, 68% of small molecules approved were oral dosage delivery?
Although drug delivery innovations in other areas may receive more excitement and coverage, for…
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Insights into the Multiscale Lubrication Mechanism of Edible Phase Change Materials
Investigation of a lubrication behavior of phase change materials (PCM) can be challenging in applications involving relative motion, e.g., sport (ice skating), food (chocolates), energy (thermal storage), apparel (textiles with PCM), etc. In oral tribology, a phase change often occurs in a sequence…
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