Pharma Excipients
Solids
Transform Your Brick-Dust API into an Effective oral Drug Candidate with Apinovex Polymers
Lubrizol Apinovex™ polymers can be easily incorporated into your drug project via spray drying or other solvent-based processes. This novel excipient has a broad API and solvent compatibility to produce Amorphous Solid Dispersions (ASD) of your brick-dust API.
1. Unlock the Potential Of…
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Solubility Enhanced Formulation Approaches to Overcome Oral Delivery Obstacles of PROTACs
PROteolysis TArgeting Chimaeras (PROTACs) offer new opportunities in modern medicine by targeting proteins that are undruggable to classic inhibitors. However, due to their hydrophobic structure, PROTACs typically suffer from low solubility, and oral bioavailability remains challenging. At the same…
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Improving in vivo oral bioavailability of a poorly soluble drug: a case study on polymeric versus…
Poorly soluble drugs must be appropriately formulated for clinical use to increase the solubility, dissolution rate, and permeation across the intestinal epithelium. Polymeric and lipid nanocarriers have been successfully investigated for this aim, and their physicochemical properties, and in…
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Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles…
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral…
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Solid Lipid Microparticles by Spray Congealing of Water/Oil Emulsion: An Effective/Versatile Loading…
Spray congealing technique was exploited to produce solid lipid microparticles (SLMp) loaded with a highly water-soluble drug (metoclopramide hydrochloride) dissolved in the aqueous phase of a water in oil (W/O) emulsion. The use of an emulsion as starting material for a spray congealing treatment…
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Investigation of hot melt extrusion process parameters on solubility and tabletability of…
Reports in the literature indicate that hot-melt extrusion (HME) processing techniques could alter the mechanical properties of the pharmaceutical physical blend, which may alter successful processing during tableting. The aim of this study was to evaluate whether HME processing conditions have an…
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A functional study of tubing material for the spray drying of mRNA-lipoplexes
Kiel University, Germany, and Meggle GmbH & Co. KG present "A functional study of tubing material for the spray drying of mRNA-lipoplexes":
INTRODUCTION
The overall aim of this project is the development of an inhalable dry powder platform for mRNA vaccines.
As many viral infections…
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Downstream Processing of Amorphous Solid Dispersions into Orodispersible Tablets
The formulation development of amorphous solid dispersions (ASDs) towards a patient-friendly oral solid dosage form is proving to be still challenging. To increase patient’s compliance orodispersible tablets (ODTs) can be seen as promising alternative. Two different ASDs were prepared via hot melt…
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Microcrystalline cellulose promotes superior direct compressed Boesenbergia rotunda (L.) Mansf.…
This work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf. extract tablet. Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried rice starch, and spray-dried lactose were used. MCC exhibited superior performance to the other diluents by providing the…
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The Preparation of Vitamin E Tablets with Fujicalin
See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin® and a comparison with the other commercially available DCPAs.
Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and…
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