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Solubility Enhancement
Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular disease. However, enhancements to Lut stability and solubility remain challenges to be addressed in the healthcare industry. Herein, we fabricated and…
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Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation,…
Drug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent. However, the clinical translation is limited by the drug‘s poor…
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Formulation and dermal delivery of a new active pharmaceutical ingredient in an in vitro wound model…
The aim of this study was to investigate dermal delivery of the new active pharmaceutical ingredient (API) TOP-N53 into diabetic foot ulcer using an in vitro wound model consisting of pig ear dermis and elucidate the impact of drug formulation and wound dressing taking into consideration clinical…
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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of…
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with…
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A review of hot melt extrusion technology: Advantages, applications, key factors and future…
Abstract
After decades of development, hot melt extrusion (HME) technology has matured as a well-established pharmaceutical methodology. Through the process of extruding both drug and carrier materials in a molten state under specific conditions of pressure, velocity, and screw design, this…
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Using Βeta-cyclodextrin and Plasdone K-30 Polymers for Enhancing Drug Solubility by Spray Drying
Abstract
The purpose of this study was to investigate improving solubility using hydrophilic/water-soluble polymers as β-Cyclodextrin and Plasdone K-30 in a solid dispersion formulation of Carvedilol a poorly soluble drug. The developed solid dispersion consisted of two components, a drug…
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Dual drug-loaded polymeric mixed micelles for ovarian cancer: Approach to enhanced therapeutic…
Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing a dual drug-loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX), encapsulated in a novel carrier matrix of D-tocopheryl polyethylene…
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Self-Nano-Emulsifying Drug-Delivery Systems: A Limelight on the Development, Advancements and…
Abstract
Back ground: Orally administered medication solubility is a key concern for the pharmaceutical business; about 35-40% of newly introduced pharmaceuticals have less aqueous solubility, resulting in deprived dissolution and limited bio-availability. Employment of lipid-oriented drug release…
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Systematic Development of Hot Melt Extrusion-Based Amorphous Solid Dispersion: Integrating Quality…
Abstract
Purpose
The study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the carrier and vitamin E TPGS as the surfactant to enhance solubility and dissolution, and to utilize in silico Physiologically Based Biopharmaceutics…
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Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease
Abstract
Purpose
This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy.
Methods
Tween® 80 and Soluplus® were evaluated to enhance the water solubility of IVM powder. Three dissolving MAPs were fabricated using…
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