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Solubility Enhancement
Development of a Carvedilol Oral Liquid Formulation for Paediatric Use
Carvedilol (CARV) is an ‘off-label’ β-blocker drug to treat cardiovascular diseases in children. Since CARV is nearly insoluble in water, only CARV solid forms are commercialized. Usually, CARV tablets are manipulated to prepare an extemporaneous liquid formulation for children in hospitals. We…
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A Potential Breakthrough in the Enhancement of Glimepiride Solubility and Dissolution Rate by Binary…
Abstract
Purpose
Glimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type, is characterized by its low solubility and high permeability. In order to increase glimepiride’s aqueous solubility and hence increase its…
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Positive Preclinical Results Unveiled for DPH001
August 23, 2023, Disruptive Pharma Announcement by Peter Åsberg
We're delighted to share positive results from our recent preclinical study for DPH001. With our innovative MMC technology, researchers at Disruptive Pharma AB have engineered an improved sorafenib formulation intended for the…
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In Silico Screening as a Tool to Prepare Drug-Drug Cocrystals of Ibrutinib-Ketoconazole: a Strategy…
Ibrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton’s tyrosine kinase (BTK) inhibitor. IBR has an extremely low oral bioavailability due to the activity of the CYP3A4 enzyme. The current intention of the research was to enhance solubility…
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Dissolution-permeation of hot-melt extruded amorphous solid dispersion comprising an experimental…
Background and purpose: Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate (HPMCAS-MX) with lower glass transition temperature have been previously investigated. This study aimed to evaluate…
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Hydrogenated phospholipid, a promising excipient in amorphous solid dispersions of fenofibrate for…
Amorphous solid dispersions (ASD) represent a viable formulation strategy to improve dissolution and bioavailability of poorly soluble drugs. Our study aimed to evaluate the feasibility and potential role of hydrogenated phospholipid (HPL) as a matrix material and solubilizing additive for binary…
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Spray drying robot for high-throughput combinatorial fabrication of multicomponent solid dispersions
During the development of pharmaceutical spray-dried formulations, many samples must be prepared for physico-chemical characterisation and dissolution testing by systematically varying parameters such as drug loading or the grades and ratios of excipients (polymers, surfactants, etc.). When spray…
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Advances in the Development of Amorphous Solid Dispersions: the Role of Polymeric Carriers
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level. To prepare the solid dispersions, there are many polymers with various…
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Development and evaluation of febuxostat solid dispersion through screening method
Febuxostat (Febux) is a BCS II drug and has a very low solubility. In order to overcome this shortcoming, the purpose of study is to increase the in vitro dissolution (%) and drug release (%) of Febux by using a screening method. The Febux-SD formulation was prepared by screening solubilizers, pH…
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Evaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic…
Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus® and poly(lactide) copolymer. The presence of “ene” groups on PJL’s backbone…
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