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Solubility Enhancement
PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release
Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with the aim of enhancing solubility and in vitro release of the…
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Formulation Development, Optimization, and Characterization of Entrectinib-Loaded Supersaturable…
Entrectinib is a novel potent anticancer drug with poor aqueous solubility. A supersaturable self-nanoemulsifying drug delivery system of entrectinib is developed using a super saturation promoter. The components of the isotropic mixture of SNEDDS were selected based on solubility and emulsification…
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Overcoming Excipient Risks and Challenges for Parenteral Formulations – Merck article
ATTRIBUTES OF EXCIPIENTS FOR HIGH-RISK FORMULATIONS
Excipients play an important role in parenteral formulations, which are high-risk given their route of administration. They protect, support, and enhance stability and bioavailability, modulate release of the API, and can enhance effectiveness of…
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A High Throughput Approach of Selecting Excipients for Solubility Enhancement of BCS Class II Active…
Scientists have been faced with the challenge of selecting the right solubilizing excipients for solubility enhancement of poorly water-soluble active pharmaceutical ingredients for decades. In this investigation, the purpose was to ease some of those challenges by developing a first-intent matrix…
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Maintaining supersaturation generation and protein integrity of amorphous curcumin-albumin nanoplex…
Amorphous curcumin-albumin nanoplex (size ≈ 100 nm, 55 wt% curcumin content) is a highly promising nanoscale delivery system of curcumin attributed to its high curcumin's payload and kinetic solubility. Its storage stability, however, has not been established. Previously, freeze-dried nanoplex with…
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Unlock the Potential of Poorly Soluble Drugs with Apisolex™ Technology
Don’t let poor solubility affect your innovative drug projects
Approximately 60% of potential active pharmaceutical ingredients (APIs) under development, and more than 40% of those in reformulation, are poorly water soluble1. Solubility challenges present a substantial hurdle to the development…
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Polymer- and Lipid-Based Nanocarriers for Ocular Drug Delivery: Current Status and Future…
Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains a huge challenge due to multiple ocular barriers that significantly affect…
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Hot Melt Extruded Posaconazole-Based Amorphous Solid Dispersions—The Effect of Different Types of…
Four model polymers, representing (i) amorphous homopolymers (Kollidon K30, K30), (ii) amorphous heteropolymers (Kollidon VA64, KVA), (iii) semi-crystalline homopolymers (Parteck MXP, PXP), and (iv) semi-crystalline heteropolymers (Kollicoat IR, KIR), were examined for their effectiveness in…
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Bioequivalence Dissolution Test Criteria for Formulation Development of High Solubility-Low…
The purpose of the present study was to provide the experimental and theoretical basis of bioequivalence (BE) dissolution test criteria for formulation development of high solubility-low permeability drugs. According to the biowaiver scheme based on the biopharmaceutics classification system (BCS),…
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Updates on applications of low-viscosity grade Hydroxypropyl methylcellulose in coprocessing for…
Hydroxypropyl methylcellulose (HPMC) is an important polymeric excipient. Its versatility in terms of molecular weights and viscosity grades is the basis for its wide and successful application in the pharmaceutical industry. Low viscosity grades of HPMC (like E3 and E5) have been used as physical…
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