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Solubility Enhancement
Challenges and Strategies for Solubility Measurements and Dissolution Method Development for…
This manuscript represents the view of the Dissolution Working Group of the IQ Consortium on the challenges of and recommendations on solubility measurements and development of dissolution methods for immediate release (IR) solid oral dosage forms formulated with amorphous solid dispersions. …
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Investigation of hot melt extrusion process parameters on solubility and tabletability of…
Reports in the literature indicate that hot-melt extrusion (HME) processing techniques could alter the mechanical properties of the pharmaceutical physical blend, which may alter successful processing during tableting. The aim of this study was to evaluate whether HME processing conditions have an…
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A Current Overview of Cyclodextrin-Based Nanocarriers for Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals,…
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Parteck MXP Excipients for Hot Melt Extrusion
Two Polyvinyl Alcohol Grades Providing Excellent Performance for Solubility Enhancement and Stabilization
Poor solubility of APIs is a critical challenge in drug development. One formulation technique to address this challenge is hot melt extrusion (HME). Mercks Parteck® MXP range of polymers…
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Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and…
The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug. The aims of this study were to assess the solubility of BCT in different solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to…
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Self-nano Emulsifying Formulations: An Encouraging Approach for Bioavailability Enhancement and…
Abstract
Currently lipid-based formulations are playing a vital and promising role in improving the oral bioavailability of poorly water-soluble drugs. Lipid based formulations mainly consist of a drug dissolved in lipids such as triglycerides, glycerides, oils and surface active agent.…
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Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations
The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e., the drying process) faces several challenges, and overall mastering depends on the end step. The advent of new emerging technologies paved…
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BASF Pharma Solutions excipient accepted into FDA Pilot Program for novel excipients – Press…
Florham Park, New Jersey, December 5, 2022 –
BASF Pharma Solutions, a global business unit of BASF, announces today that the U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of New Drugs, has accepted their excipient, Soluplus®, into the FDA’s Pilot…
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Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody
COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the preferred route of administration, even for local…
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In Situ Co-Amorphization of Olanzapine in the Matrix and on the Coat of Pellets
In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during conventional processing. The production of pellets by…
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