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Solubility Enhancement
Oral delivery of camptothecin-loaded multifunctional chitosan-based micelles is effective in reduce…
Colorectal cancer (CRC) is a heterogeneous disease with high incidence and mortality worldwide. The efficacy of conventional CRC chemotherapy is hampered by poor drug solubility and bioavailability and suboptimal pharmacokinetic profiles. In this work, camptothecin (CPT), a potent anticancer drug,…
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Development and exploration on flowability of solid self-nanoemulsifying drug delivery system of…
Morin hydrate (MH) is a promising flavonoid with diverse biological activities; unfortunately, it finds limited clinical application due to its low water solubility. Herein, we developed a liquid self nano-emulsifying drug delivery system (l-SNEDDS) employing Labrafil M 1944 CS, Cremophor RH 40, and…
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Low-surfactant microemulsion, a smart strategy intended for curcumin oral delivery
This study aimed to develop a low surfactant concentration curcumin-loaded microemulsion (Curc-ME) having a gastrointestinal pH resistance, intended to prospect its oral use for further curcumin release. The effect of excipients on the apparent solubility of curcumin was assessed and a pseudo…
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Formulation of Plumbagin Loaded Microemulsion: Evaluation of Anti-rheumatoid efficacy in Wistar Rat…
Rheumatoid arthritis has become a common disease among the elderly. Plumbagin, a plant-derived chemical, has been shown to lower the levels of proinflammatory cytokines and interleukins linked to rheumatoid arthritis progression. The objective of the present research work was to assess the…
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Safety and Pharmaceutical Evaluation of a Novel Natural Polymer, Ocicum, as Solubility and…
Plant mucilages are commonly employed as excipients in pharmaceutical manufacturing. Ocimum basilicum (Lamiaceae family), a source of hydrophilic mucilage referred herein as Ocicum, was evaluated for the solubility enhancer of a model drug, aceclofenac, in solid dispersions prepared using different…
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Design, characterization and in vivo performance of solid lipid nanoparticles (SLNs)-loaded…
Lornoxicam (LRX) is a potent nonsteroidal anti-inflammatory drug (NSAID) used extensively to manage pain and inflammatory conditions. However, the drug possesses poor aqueous solubility (i.e., BCS class II) and a short half-life (3–4 h). Mucoadhesive buccal tablets containing LRX -loaded solid lipid…
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Strategies for enhancing the oral bioavailability of cannabinoids
Introduction
Oral administration of cannabinoids is a convenient route of administration in many cases. To enhance the poor and variable bioavailability of cannabinoids, selected strategies utilizing proper delivery systems have been designed. Low solubility in the GI aqueous media is the first…
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From Bitter to Sweet: a preliminary study towards a patient-friendly Praziquantel dosage form
Praziquantel (PZQ) is an antihelmintic drug used worldwide against Schistosomiasis, despite its low solubility, bioavailability and the disgusting taste. This research represents a preliminary screening of 6 selected sweeteners in terms of their aptitude to be ground with PZQ, towards the…
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Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for the enhancement of TCG solubility and permeability. Herein, we have developed the TCG high-loaded nanostructured lipid carrier (HL-NLC) and solidified…
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Based on functional materials and PLGA for the florfenicol controlled release system and its…
It is widely used PLGA in synthesizing active drug nanoparticles due to its high biocompatibility, biodegradability, and pelletization. In this study with PLGA as the carrier, the florfenicol nanoparticles (FF-PLGA NPs) were investigated to improve water solubility and controlled drug release for…
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