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Solubility Enhancement
Kollidon® VA 64 and Soluplus® as modern polymeric carriers for amorphous solid dispersions
As the number of new drug candidates that are poorly soluble in water grows, new technologies that enable the enhancement of their solubility are needed. This is the case with amorphous solid dispersions (ASDs) that, nowadays, not only ensure the solubility, but can also be used to control the …
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Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery…
Cyclodextrins (CDs) are a family of cyclic oligosaccharides, consisting of a macrocyclic ring of glucose subunits linked by α-1,4 glycosidic bonds. The shape of CD molecules is similar to a truncated cone with a hydrophobic inner cavity and a hydrophilic surface, which allows the formation of…
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Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses:…
While the intranasal administration of drugs to the brain has been gaining both research attention and regulatory success over the past several years, key fundamental and translational challenges remain to fully leveraging the promise of this drug delivery pathway for improving the treatment of…
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Hydrogel-forming microarray patches with cyclodextrin drug reservoirs for long-acting delivery of…
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and prolonged drug delivery. These devices are designed to be self-administered and self-disabling, avoiding contaminated sharps waste generation. Cabotegravir sodium (CAB-Na) is a poorly soluble anti-human…
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Long acting injectables for therapeutic proteins
Biotherapeutic development presents a myriad of challenges in relation to delivery, in particular for protein therapeutics. Protein delivery is complicated due to hydrophilicity, size, rate of degradation in vivo, low permeation through biological barriers, pH and temperature sensitivity, as well as…
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Chitosan/sulfobutylether-β-cyclodextrin based nanoparticles coated with thiolated hyaluronic acid…
Indomethacin (IND) is topically administered for the treatment of the anterior segment diseases such as conjunctivitis, uveitis, and inflammation prevention for post-cataract surgery, as well as posterior segment diseases as macular edema. Currently IND is available as 0.1% w/v…
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Labrasol Mediated Enhanced Solubilization of Natural Hydrophobic Drugs in Pluronic Micelles:…
In present work, the solubilization of two natural hydrophobic drugs Quercetin (QCT) and Curcumin (CUR) has been systematically investigated in Pluronics (P84, F127, F68) and Pluronics-Labrasol mixed micelles. UV-Visible studies confirmed that the solubility, drug loading efficiency, partition…
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Self-emulsifying Drug Delivery System for Praziquantel with Enhanced Ex Vivo Permeation
Purpose
In this work, praziquantel (PZQ) was incorporated into self-emulsifying drug delivery system (SEDDS) formulations to demonstrate that the increased apparent solubility and dissolution rate enhance intestinal permeation.
Methods
Solubility measurements of PZQ were performed in lipid…
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Injectable Formulations of Poorly Water-Soluble Drugs
Each year, an increasing number of new molecular entities in the drug development pipeline are characterized as having poor water solubility. While solubility limitations are critically important in all formulations, failure to properly understand and address solubility challenges in parenteral…
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Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs
Poor aqueous solubility of new chemical entities presents various challenges in the development of effective drug delivery systems for various delivery routes. Poorly soluble drugs that are delivered orally may commonly result in low bioavailability and are often subject to considerable food…
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