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Solubility Enhancement
Soluplus® polymeric nanomicelles improve solubility of BCS-class II drugs
The issue of poor aqueous solubility is often a great hitch in the development of liquid dosage forms for those drugs that the Biopharmaceutics Classification System (BCS) includes in classes II and IV. Among the possible technological solutions, inclusion of the drug molecule within polymeric…
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Incorporation of itraconazole nano-co-crystals into multiparticulate oral dosage forms
Limited research has been performed on the downstream processing of nano-co-crystal suspensions into solid oral dosage forms. The objectives of this study were to evaluate the impact of three downstream processes (wet granulation, spray granulation and bead layering) on the performance of…
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A Hot-Melt Extrusion Risk Assessment Classification System for Amorphous Solid Dispersion…
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations via the hot-melt extrusion (HME) technique. However,…
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Influence of Oil Phase Surface Properties on the Physicochemical Characteristics of Meloxicam…
Introduction
Preparation of self-microemulsifying drug delivery systems (SMEDDS) is a promising delivery approach for drugs with poor aqueous solubility to enhance their dissolution properties and hence oral bioavailability. The objective of the present study was to define the influence of the oily…
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Spray-dried indomethacin-loaded polymeric micelles for the improvement of intestinal drug release…
Current study aimed to develop a spray-dried powder containing indomethacin (IND)-loaded polymeric micelles which can be administered perorally as a dissolved powder to enhance the drug release and permeability of the active substance. The resulting low dense spray-dried spherical particles have…
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Prototypes of Nutraceutical Products From Microparticles Loaded With Stilbenes Extracted From Grape…
Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in commercial goods.
This research aimed to improve knowledge…
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Spray-Drying of Hydroxypropyl β-Cyclodextrin Microcapsules for Co-Encapsulation of Resveratrol and…
The synergistic therapeutic benefits of resveratrol (RES) and piperine (PIP) have been proven for the treatment of various diseases. This study reports, for the first time, spray-drying of hydroxypropyl β-cyclodextrin (HP-β-CD) microcapsules for combined delivery of resveratrol and piperine. Phase…
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Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug…
Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first pass metabolism and poor solubility. To enhance dissolution and in vivo effects, Lov solid self microemulsifying drug delivery system (SMEDDS) and liquisolid systems were developed and evaluated to select…
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How to improve topical formulations of poorly-water soluble APIs
Solubility of an Active Pharmaceutical Ingredient (API) in the dosage form is a key parameter in topical formulation. Poor solubility can negatively impact the API drug load, its stability in the dosage form as well as its skin permeation behavior.
Polar solvents such as PEG-400, diethylene…
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Fast In Vitro Release and In Vivo Absorption of an Anti-Schizophrenic Drug Paliperidone from Its…
The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a more effective therapeutic strategy for patients with acute schizophrenia. PPD-loaded Soluplus®/TPGS mixed micelles (PPD-S/T-MM) were prepared using the thin-film hydration method. The…
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